ＲＯＣＫ阻害剤としてのスピロヘプタンサリチルアミドおよび関連性化合物

Japanese Patent JP6976953

B2

The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Leon M Smith the Second
Vladimir Radiata
Indawati Delkka
Donald Jay P. Pinto
Michael Jay Owat
Andrew Kay Dilger
Kumar Balashanmuga Paviseti
Wu Yang
Scott A Show
Peter W. Grants
Manolan Jean Panda

JP2018536481A

December 08, 2021

January 13, 2017

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BRISTOL-MYERS SQUIBB COMPANY

C07D209/08; A61K31/17; A61K31/27; A61K31/4035; A61K31/404; A61K31/415; A61K31/416; A61K31/437; A61K31/44; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/498; A61K31/4985; A61K31/501; A61K31/5025; A61K31/506; A61K31/517; A61K31/536; A61K31/5377; A61K31/5386; A61K31/54; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P21/00; A61P25/00; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07C271/24; C07C275/34; C07D209/42; C07D209/44; C07D213/82; C07D215/54; C07D231/12; C07D231/14; C07D231/56; C07D233/60; C07D249/06; C07D265/18; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D487/04; C07D498/08; C07D513/04; C07D519/00

JP2017520604A
JP2010514716A

WO2007142323A1

Norihito Yamao
Nagatoshi Shinagawa
Kure Hidenori
Kamahira Futami
Mizuhara Masahiro

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