Title:
噴霧乾燥装置および使用方法
Document Type and Number:
Japanese Patent JP5412022
Kind Code:
B2
Abstract:
Improved spray drying apparati, and methods of use thereof, have been developed. The spray drying equipment includes a primary drying chamber and a secondary drying apparatus which includes tubing having a length sufficient to increase the contact time between the drying gas and the droplets/particles to dry the particles to the extent desired, at a drying rate and temperature which would be too low to provide adequate drying without the secondary drying apparatus. The secondary drying apparatus increases the drying efficiency of the spray dryer system without increasing the drying rate, while minimizing loss in yield The ratio of the length of tubing to the length of the primary drying chamber is at least 2:1. The tubing diameter is substantially smaller than the diameter of the primary drying chamber, such that the particles move at higher velocity through the tubing to minimize product losses. The ratio of the cross-sectional area of the primary drying chamber to the cross-sectional area of the tubing most preferably is about 16:1. The tubing preferably is in a compact coil design, which can more easily be transported and which has minimum space requirements, and may optionally include a jacket to control the temperature of the secondary drying process. A preferred application for the spray drying process and equipment is in the production of polymeric microparticles, between about 1 and 200 mum in diameter, which can be used to deliver therapeutic and diagnostic agents.
Inventors:
Ticker Ring, Donald Yee
Keegan, Mark Jay
Randall, Greg
Bernstein, Howard
Strobe, Julie
Keegan, Mark Jay
Randall, Greg
Bernstein, Howard
Strobe, Julie
Application Number:
JP2000615133A
Publication Date:
February 12, 2014
Filing Date:
April 26, 2000
Export Citation:
Assignee:
Hobionet Intel Limited
International Classes:
B01D1/18; F26B3/06; A61K9/16; B01J2/04; F26B17/10; F26B17/16; F26B23/10
Domestic Patent References:
| JP6161601A | ||||
| JP6387582A | ||||
| JP5878102U |
Attorney, Agent or Firm:
Toru Ishikawa
Hisako Ishido
Hisako Ishido