Title:
安定なタンパク質組成物
Document Type and Number:
Japanese Patent JP7179112
Kind Code:
B2
Abstract:
Stable pharmaceutical formulations and drug delivery devices are disclosed. In certain embodiments, the drug delivery device contains a reservoir when implanted into a patient is in partial contact with the tissue environment. The reservoir remains in contact with the environment via a porous structure in the housing of the delivery device. The reservoir contains a combination of the therapeutic biomolecule and a second molecule that serves to stabilize and restrict the solubility of the therapeutic biomolecule, thereby controlling the amount of therapeutic biomolecule that is in solution. The concentration of the soluble therapeutic biomolecule or the size of the surface area of the porous structure controls the rate of delivery of the therapeutic biomolecule to the target tissue.
Inventors:
Chen Hunter
Erika Schlesinger
Erika Schlesinger
Application Number:
JP2021038817A
Publication Date:
November 28, 2022
Filing Date:
March 11, 2021
Export Citation:
Assignee:
REGENERON PHARMACEUTICALS, INC.
International Classes:
A61K9/10; A61K39/395; A61K47/10; A61P27/02; A61P35/00
Domestic Patent References:
| JP2018538243A | ||||
| JP2009540001A |
Foreign References:
| US20160376342 |
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
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