Title:
安定な放射性ヨウ素結合物とそれらの合成方法
Document Type and Number:
Japanese Patent JP3965019
Kind Code:
B2
Abstract:
Methods are described for conjugating radioiodinated peptides or carbohydrate structures to proteins with improved yields and qualities of conjugates. In one method, specially designed radioiodinated bifunctional peptides containing nonmetabolizable bonds such as amide bonds are coupled to cell targeting protein. In a second method, radioiodinated nonmetabolizable bifunctional peptides, which also contain aminopolycarboxylates, are coupled to protein. In a third method, radioiodinated bifunctional aminopolycarboxylates are coupled to protein. In a fourth method, a hydrazide-appended protein is coupled to a radioiodinated carbohydrate or a thiolated protein is coupled to a hydrazide-appended and radioiodinated carbohydrate. In a fifth method a monoderivatized cyanuric chloride is used to conjugate thiolated protein. Radioiodinated residualizing protein conjugates made by these methods are particularly stable in vivo and are suitable for radioimmunodetection and radioimmunotherapy.
More Like This:
| JP4365223 | Radioactive fluorination method |
| JP2010532321 | Marking method |
| JP2014065919 | CYANINE DYES |
Inventors:
Govindan, Serengram Vui
Gary Elle, Griffith
Gary Elle, Griffith
Application Number:
JP2000508395A
Publication Date:
August 22, 2007
Filing Date:
December 19, 1997
Export Citation:
Assignee:
Immunomedics, Inc.
International Classes:
C07K1/13; A61K49/00; G01N33/534; A61K51/00; A61K51/04; A61K51/08; A61K51/10; C07H3/04; C07K1/107; G01N33/543; G01N33/60
Domestic Patent References:
| JP3173900A |
Foreign References:
| WO1996016677A1 |
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo