Title:
STABLE MIA/CD-RAP FORMULATION
Document Type and Number:
Japanese Patent JP2016034958
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide stable formulations with high concentrations of CD-RAP, where it is thought that interaction between CD-RAP and specific epitopes in extracellular matrix proteins regulates attachment of tumor cells and chondrocytes.SOLUTION: A stable aqueous formulation comprises at least 5 mg/mL CD-RAP, and a charged amino acid selected from among glycine, arginine, histidine, aspartic acid, glutamic acid and salts thereof, the amino acid having a concentration of 1-8 w/v%, and further comprises a buffer, a tonicity modifier, a stabilizer and an excipient, having a net charge at a pH of 6-8. The ingredients of the formulation provide stability over repeated freeze-thaw cycles. The formulation is for use in treatment of inflammatory disorders, preferably osteoarthritis. Further, a kit comprising the formulation is provided.SELECTED DRAWING: None
Inventors:
KLAUS HELLERBRAND
RAINER SIGL
RAINER SIGL
Application Number:
JP2015178485A
Publication Date:
March 17, 2016
Filing Date:
September 10, 2015
Export Citation:
Assignee:
SCIL TECHNOLOGY GMBH
International Classes:
A61K38/00; A61K9/08; A61K47/18; A61P19/02; A61P29/00
Domestic Patent References:
| JP2010505785A | 2010-02-25 | |||
| JP2003527435A | 2003-09-16 | |||
| JPH11510170A | 1999-09-07 | |||
| JP2009530380A | 2009-08-27 |
Foreign References:
| US20020103360A1 | 2002-08-01 | |||
| US5580856A | 1996-12-03 |
Other References:
J BIOMOL NMR, vol. 22, JPN6015019715, 2002, pages 211 - 23, ISSN: 0003334224
BIOPHYSICAL CHEMISTRY, vol. Vol.127, Issues 1-2, JPN6014047873, 2007, pages 1 - 8, ISSN: 0003334225
BIOPHYSICAL CHEMISTRY, vol. Vol.127, Issues 1-2, JPN6014047873, 2007, pages 1 - 8, ISSN: 0003334225
Attorney, Agent or Firm:
Iseki Katsumori