Title:
TNFαを阻害する安定な可溶性抗体
Document Type and Number:
Japanese Patent JP5089582
Kind Code:
B2
Abstract:
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFa, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFa, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFa-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
Inventors:
Evert, Stephan
Barberis, Alzido
Urehi, David M
Aof der Maor, Adrian
Lichtren, Peter
Barberis, Alzido
Urehi, David M
Aof der Maor, Adrian
Lichtren, Peter
Application Number:
JP2008515021A
Publication Date:
December 05, 2012
Filing Date:
June 06, 2006
Export Citation:
Assignee:
ESBATech, an Alcon Biomedical Research Unit, LLC
International Classes:
C12N15/09; A61K39/395; A61K48/00; A61P1/04; A61P9/04; A61P11/06; A61P19/02; A61P25/00; C07K16/24; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; A61K39/00
Other References:
Molecular immunology. 1994, Vol.31, No.14, p.1059-1067
Methods. 2005 May, Vol.36, No.1, p.11-24
Journal of molecular biology. 2001, Vol.305, No.5, p.989-1010
Methods. 2005 May, Vol.36, No.1, p.11-24
Journal of molecular biology. 2001, Vol.305, No.5, p.989-1010
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Akiko Nakahama
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Akiko Nakahama