Title:
ＴＮＦαを阻害する安定な可溶性抗体
Document Type and Number:
Japanese Patent JP5645890
Kind Code:
B2
Abstract:
The present invention relates to particularly stable and soluble scFv antibodies and Fab fragments specific for TNFa, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNFa, and low immunogenicity. Said antibodies are designed for the diagnosis and/or treatment of TNFa-related disorders. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
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Inventors:
エヴェルト，シュテファン
バルベリス，アルツィド
ウーレヒ，ダーヴィット・エム
アオフ・デア・マオル，アードリアン
リヒトレン，ペーター
バルベリス，アルツィド
ウーレヒ，ダーヴィット・エム
アオフ・デア・マオル，アードリアン
リヒトレン，ペーター
Application Number:
JP2012161794A
Publication Date:
December 24, 2014
Filing Date:
July 20, 2012
Export Citation:
Assignee:
エスバテック − ア ノバルティスカンパニー エルエルシー
International Classes:
C12N15/09; A61K9/08; A61K31/7088; A61K35/76; A61K39/395; A61K45/00; A61K47/10; A61K47/12; A61K47/24; A61K47/26; A61K47/34; A61K48/00; A61P1/00; A61P19/02; A61P27/02; A61P29/00; C07K16/24; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; G01N33/53; G01N33/531; A61K39/00
Attorney, Agent or Firm:
Ono Shinjiro
Kobayashi 泰
Hiroyuki Tomita
Hoshino 修
Akiko Nakahama
Kobayashi 泰
Hiroyuki Tomita
Hoshino 修
Akiko Nakahama