STAINING COMPOSITION IN VIVO FOR CONFIRMING MALFORMED TISSUE, ITS PRODUCTION AND ITS USAGE

Japanese Patent JPH11209357

A

To obtain a stable-quality staining composition with high toluidine blue-O proportion, to provide a method for producing the composition, also to provide a method for confirming malformed tissue using the composition, and to provide a method for analyzing the composition.

This method for producing the subject staining composition comprises oxidation of N,N-dimethyl-p-phenylenediamine to form 2-amino-5- dimethylaminophenylthiosulfonic acid followed by its oxidation and then condensation reaction with o-toluidine to form indaminethiosulfonic acid which, in turn, is oxidized to effect cyclization of the indamine ring to produce a reaction product containing toluidine blue-O(TBO); wherein, prior to forming the reaction product, a complexing reagent is introduced into the system.

BURKETT DOUGLAS D

JP29560798A

August 03, 1999

October 16, 1998

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ZILA INC

A61B10/00; C07D279/20; C09B21/00; C09B67/22; G01N30/88; G01N30/02; (IPC1-7): C07D279/20; A61B10/00; C09B67/22; G01N30/88

US0416055A	1889-11-26
US0416055A	1889-11-26

JPN6009039252, ＲＯＹＢＡＬ，　Ｊ　Ｅ．　ｅｔ　ａｌ．, "ＡＰＰＬＩＣＡＴＩＯＮ　ＯＦ　ＥＬＥＣＴＲＣＨＥＭＩＣＡＬ　ＡＮＤ　ＵＶ／ＶＩＳＩＢＬＥ　ＤＥＴＥＣＴＩＯＮ　ＴＯ　ＴＨＥ　ＬＣ　ＳＥＰＡＲＡＴＩＯＮ　ＡＮＤ　ＤＥＴＥＲＭＩＮＡＴＩＯＮ　ＯＦ　ＭＥＴ", Ａｎａｌｙｓｉｓ　ｏｆ　Ａｎｔｉｂｉｏｔｉｃ　Ｄｒｕｇ　Ｒｅｓｉｄｕｅｓ　ｉｎ　Ｆｏｏｄ　Ｐｒｏｄｕｃｔｓ　ｏｆ　Ａｎｉｍａｌ　Ｏｒｉｇｉｎ, 1991, ｐ．１９７−２１０, Ａ　Ｄｉｖｉｓｉｏｎ　ｏｆ　Ｐｌｅｎｕｍ　Ｐｕｂｌｉｓｈｉｎｇ　Ｃｏｒｐｏｒａｔｉｏｎ
JPN6009039251, ＭＣＫＡＭＥＹ，　Ｍ　Ｒ．　ａｎｄ　ＳＰＩＴＺＮＡＧＬＥ，　Ｌ　Ａ．, "Ｃｈｒｏｍａｔｏｇｒａｐｈｉｃ，　Ｍａｓｓ　Ｓｐｅｃｔｒａｌ，　ａｎｄ　Ｖｉｓｉｂｌｅ　Ｌｉｇｈｔ　Ａｂｓｏｒｐｔｉｏｎ　Ｃｈａｒａｃｔｅｒｉｓｔｉｃｓ　ｏｆ　Ｔｏｌｕｉｄｉｎｅ　Ｂｌｕｅ　Ｏ　ａｎｄ", Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｓｃｉｅｎｃｅｓ, 1975, Ｖｏｌ．６４，　Ｎｏ．９, ｐ．１４５６−１４６２

Tadashi Hagino (3 outside)

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