Title:
拍動する心筋細胞へ形質転換する幹細胞
Document Type and Number:
Japanese Patent JP4377690
Kind Code:
B2
Abstract:
Disclosed herein is a novel isolated population of stem cells, called spoc cells, that can be induced, either in vivo or in vitro, to differentiate into cardiomyocytes. Methods are disclosed herein to differentiate the spoc cells, and to utilize these spoc cells for screening agents that affect cardiomyocytes. Methods are also provided herein to utilize spoc cells in therapeutic applications for the treatment of myocardial defects, such as areas of ischemic or traumatic damage.
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Inventors:
Ipstein Neil Dee.
Gopal sill buoy.
Winitski Steve O.
Hassan the Day Shaheen
Gopal sill buoy.
Winitski Steve O.
Hassan the Day Shaheen
Application Number:
JP2003538339A
Publication Date:
December 02, 2009
Filing Date:
October 22, 2002
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
G01N33/48; A61K35/34; A61L27/00; A61P9/00; A61P9/10; A61P21/00; C12N5/02; C12N5/077; C12N5/10; C12N15/09; C12Q1/02; G01N33/15; G01N33/50; A61K35/12
Domestic Patent References:
| JP2003259863A | ||||
| JP2003325169A |
Foreign References:
| WO2001048151A1 | ||||
| WO2003027281A1 | ||||
| WO2004101775A1 |
Other References:
J.Cell Biol.,1994,Vol.125,No.6,p.1275-1287
Nature,1999,Vol.401,p.390-394
J.Cell Biol.,2002.05,Vol.157,No.4,p.571-577
Nature,1999,Vol.401,p.390-394
J.Cell Biol.,2002.05,Vol.157,No.4,p.571-577
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi