Title:
生分解性ヒドロゲルの滅菌
Document Type and Number:
Japanese Patent JP5893566
Kind Code:
B2
Abstract:
The present invention relates to a terminal sterilization process for biodegradable PEG-based insoluble hydrogels using irradiation. The presence of a protective solvent ensures that the hydrogel remains intact with functionally preserved three-dimensional and physicochemical properties.
Inventors:
Lau, Harald
Voigt, Tobias
Hellzel, Ulrich
Voigt, Tobias
Hellzel, Ulrich
Application Number:
JP2012535835A
Publication Date:
March 23, 2016
Filing Date:
October 28, 2010
Export Citation:
Assignee:
Ascendis Pharma A/S
International Classes:
A61L2/08; A61K9/06; A61L17/00; A61L27/00
Domestic Patent References:
| JP2002531217A | ||||
| JP2011511880A | ||||
| JP2008228744A |
Foreign References:
| WO2007140312A1 | ||||
| US20070275030 |
Other References:
D.Attwood, et al.,Influence of gamma irradiation on the rheological properties of gels of the poloxamine, Synperonic T908,INTERNATIONAL JOURNAL OF PHARMACEUTICS,NL,ELSEVIER BV,1991年 3月31日,Volume 70,Issues1-2,Pages 147-152
Martina B. Sintzel, et.al.,Influence of Irradiation Sterilization on Polymers Used as Drug Carriers-A Review,米国,1997年,Volume 23,No.9,Pages 857-878
Martina B. Sintzel, et.al.,Influence of Irradiation Sterilization on Polymers Used as Drug Carriers-A Review,米国,1997年,Volume 23,No.9,Pages 857-878
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka