Title:
ステロイド誘導体
Document Type and Number:
Japanese Patent JP2005508281
Kind Code:
A
Abstract:
A compound of formula (1): wherein each of R1, R2, R4, R4', R7, R11, R12, R15, R16, R17, and R17', independently, is hydrogen, hydroxy, amino, carboxyl, oxo, halo, sulfonic acid, -O-sulfonic acid, or alkyl that is optionally inserted with -NH-, -N(alkyl)-, -O-, -S-, -SO-, -SO2-, -O-SO2-, -SO2-O-, -SO3-O-, -CO-, -CO-O-, -O-CO-, -CO-NH-, -CO-N(alkyl)-, -NH-CO-, or -N(alkyl)-CO-, and further optionally substituted with hydroxy, halo, amino, carboxyl, sulfonic acid, or -O-sulfonic acid; R3 is X-Y-, wherein X is hydrogen, amino, carboxyl, halo, sulfonic acid, -O-sulfonic acid, or alkyl; Y is -S-, -NH-, -N(alkyl)-, -SO-, -SO2-, -O-SO2-, -SO2-O-, -SO3-O-, -CO-, -CO-O-, -O-CO-, -CO-NH-, -CO-N(alkyl)-, -NH-CO-, or -N(alkyl)-CO-; R5 and R6, together, are -O-; or R5 and R6, together, are a double bond between C-5 and C-6, and R7 is oxo; each of R8, R9, R10, R13, and R14, independently, is hydrogen, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino; and n is 0, 1, or 2. Also disclosed are a method of treating hypocholesterolemia and a method of screening for an LXR agonist by administering a compound described above, a pharmaceutical composition containing at least one of the compounds described above, and an antibody against 5alpha, 6alpha-epoxycholesterol-3-sulfate or 7-ketocholesterol-3-sulfate.
Inventors:
Liao, Stung
Song, ching
Song, ching
Application Number:
JP2002562310A
Publication Date:
March 31, 2005
Filing Date:
February 07, 2002
Export Citation:
Assignee:
THE UNIVERSITY OF CHICAGO
International Classes:
A61K31/56; A61K31/565; A61K31/575; A61K31/58; A61P3/00; A61P3/06; C07J1/00; C07J9/00; C07J31/00; C07J41/00; C07J71/00; C07K16/44; G01N33/566; A61K; (IPC1-7): C07J71/00; A61K31/56; A61K31/58; A61P3/00; C07J31/00
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda