Title:
STEROID
Document Type and Number:
Japanese Patent JPS6061595
Kind Code:
A
Abstract:
Steroids of the formula I wherein n represents the number 2, 3 or 4; R1 represents hydrogen, lower-alkyl or lower-alkylidene; R2, R3 and R4 represent hydrogen or lower-alkyl and the dotted C-C bonds in the 5(6)-, 7(8)-, 22(23)-, 24(28)- and 25(26)-position are optional, whereby the B-ring can contain only one double bond and the side-chain is either saturated or is mono-unsaturated or is di-unsaturated in the 22(23), 25(26)-position; and whereby R1 is lower-alkyl or lower-alkylidene when a 5(6)-double bond is present, n is 2 and R2, R3 and R4 are methyl, and pharmaceutically acceptable salts of these steroids have activity inhibiting the intestinal resorption of cholesterol. They can be manufactured from steroids which are otherwise substituted in the 3 beta -position.
Inventors:
JIYANNMARII KATSUSARU
Application Number:
JP15778584A
Publication Date:
April 09, 1985
Filing Date:
July 30, 1984
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/685; A61P9/10; C07J9/00; A61K31/575; C07J51/00; (IPC1-7): A61K31/575; C07J9/00
Attorney, Agent or Firm:
Heikichi Odashima