Title:
生物学的に活性な特異的カーゴペプチドと結合したヒト由来の細胞透過性ペプチドの構造、製造および使用
Document Type and Number:
Japanese Patent JP6479777
Kind Code:
B2
Abstract:
Embodiments disclosed herein provide compositions for conjugates, including fusion proteins, and methods of using them to treat a variety of conditions. In some embodiments, the conjugates and/or fusion proteins incorporate a 60-amino acid human homeodomain (e.g., peptides derived from human HOX genes), to translocate functional and regulatory peptides and proteins or other biologically active molecules such as nucleic acids, which are not naturally associated with the human homeodomain, across cell and nuclear membranes to intended sites of action without provoking an unwanted immune response that may reduce exposure to the conjugate and/or result in a clinical adverse event. In further embodiments, disclosed conjugates and fusion proteins can pass through the blood-brain barrier to allow entry into the CNS. In various embodiments, the disclosed compositions are suitable for delivery into a cell (i) the expression product of a gene of interest and/or (ii) novel peptides or polynucleotides to regulate gene function.
Inventors:
Bruce H. Littman
John F. Thompson
Frank W. Marcouk
John F. Thompson
Frank W. Marcouk
Application Number:
JP2016518595A
Publication Date:
March 06, 2019
Filing Date:
June 11, 2014
Export Citation:
Assignee:
Portage Pharmaceuticals L.T.D.
Bruce H. Littman
John F. Thompson
Frank W. Marcouk
Bruce H. Littman
John F. Thompson
Frank W. Marcouk
International Classes:
C07K19/00; A61K9/72; A61K38/16; A61K47/50; A61K48/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P17/14; A61P25/00; A61P25/14; A61P27/02; A61P35/00; A61P37/02; C07K14/46
Domestic Patent References:
| JP2001514858A | ||||
| JP2008508364A | ||||
| JP2008535512A | ||||
| JP2011519558A |
Foreign References:
| KR1020110026071A |
Other References:
Drug Discovery Today,2012年,Vol.17, No.15/16,p.850-860
GenBank[online], Accession No. NP_776272,, 24-Mar-2012 uploaded, [retrieved on 2018-07-13], Definition: homeobox protein Hox-C12[Homo sapiens]
GenBank[online], Accession No. NP_067016,, 07-Jan-2013 uploaded, [retrieved on 2018-07-13], Definition: homeobox protein Hox-D12[Homo sapiens]
GenBank[online], Accession No. NP_115485,, 18-Apr-2013 uploaded, [retrieved on 2018-07-13], Definition: homeobox protein orthopedia[Homo sapiens]
GenBank[online], Accession No. NP_001182446,, 12-Jan-2013 uploaded, [retrieved on 2018-07-13], Definition: T-cell leukemia homeobox protein 1 isoform 2[Homo sapiens]
GenBank[online], Accession No. NP_776272,
GenBank[online], Accession No. NP_067016,
GenBank[online], Accession No. NP_115485,
GenBank[online], Accession No. NP_001182446,
Attorney, Agent or Firm:
Toru Ishikawa