Title:
カスパーゼの活性化因子およびアポトーシスの誘導因子としての置換された4H-クロメンおよび類似体、並びにその使用方法
Document Type and Number:
Japanese Patent JP4593880
Kind Code:
B2
Abstract:
The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the general Formula I: wherein R1-R5, A, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
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Inventors:
Kai Sui
Chang Hong
Jiang Song Chun
Store richard
Chang Hong
Jiang Song Chun
Store richard
Application Number:
JP2002589478A
Publication Date:
December 08, 2010
Filing Date:
May 16, 2002
Export Citation:
Assignee:
Sightvia Inc.
International Classes:
C07D215/54; A61K31/35; A61K31/352; A61K31/38; A61K31/382; A61K31/40; A61K31/4025; A61K31/407; A61K31/415; A61K31/4188; A61K31/44; A61K31/453; A61K31/47; A61K31/495; A61K31/496; A61K31/497; A61K31/4985; A61K31/50; A61K31/505; A61K31/506; A61K31/535; A61K31/5377; A61K33/24; A61K45/06; A61P1/00; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07D311/58; C07D311/64; C07D335/06; C07D405/04; C07D491/04; C07D491/052; C07D493/04; C07D495/04
Domestic Patent References:
| JP2003513967A | ||||
| JP7002845A | ||||
| JP5194477A |
Other References:
Organic Preparation and Procedures Int.,1999年,vol.31, No.3,305-313
Zhurnal Organicheskoi Khimii,1987年,vol.23, No.2,412-421
Zhurnal Organicheskoi Khimii,1987年,vol.23, No.2,412-421
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi