Title:
SUBSTITUTED FIVE-MEMBERED AND SIX-MEMBERED HETEROCYCLIC COMPOUND, ITS PREPARATION METHOD, COMBINATION WITH MEDICINE AND ITS USAGE
Document Type and Number:
Japanese Patent JP2021176847
Kind Code:
A
Abstract:
To provide a compound having PIKfyve Kinase selective inhibition activity, and a pharmaceutically allowable salt or its pharmaceutically allowable solvation material, its preparation method, a medical composition containing the compound, and use method of these compounds in preparation of medicine for prevention or treatment of diseases related to the PIKfyve in an organism, in particular, a use method in preparation of a medicine for preventing or treating proliferation and metastasis of tumor in particular.SOLUTION: There is provided a compound expressed by the following formula. (where R1,R2: substituted/unsubstituted C6-C10 aryl or heteroaryl. R3: H, halogen, substituted/unsubstituted alkyl or cycloalkyl.)SELECTED DRAWING: Figure 1
Inventors:
DENG XIANMING
HUANG WEI
SUN XIHUAN
ZHANG TING
HE ZHIXIANG
LIU YAN
WU XINRUI
ZHANG BAODING
LI XIAOYANG
ZHANG JINGFANG
CHEN YUN
LI LI
XU QINGYAN
HU ZHIYU
HUANG WEI
SUN XIHUAN
ZHANG TING
HE ZHIXIANG
LIU YAN
WU XINRUI
ZHANG BAODING
LI XIAOYANG
ZHANG JINGFANG
CHEN YUN
LI LI
XU QINGYAN
HU ZHIYU
Application Number:
JP2021098941A
Publication Date:
November 11, 2021
Filing Date:
June 14, 2021
Export Citation:
Assignee:
UNIV XIAMEN
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61P35/00; A61P35/02; A61P35/04; A61P43/00
Foreign References:
| WO2009070524A1 | 2009-06-04 | |||
| WO2016210291A1 | 2016-12-29 | |||
| WO2017024589A1 | 2017-02-16 | |||
| WO2017004133A1 | 2017-01-05 | |||
| CN104177363A | 2014-12-03 | |||
| WO2016210330A1 | 2016-12-29 |
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation
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