Title:
ネプリライシン阻害剤としての置換アミノ酪酸誘導体
Document Type and Number:
Japanese Patent JP5466759
Kind Code:
B2
Abstract:
The present invention provides a compound of formula I';
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Inventors:
Gary Mark Coppola
Iwaki Snow
Rajeshri Ganesh Kalki
Toshio Kawanami
Gary Michael Xander
Moteto Mogi
Robert Sun
Iwaki Snow
Rajeshri Ganesh Kalki
Toshio Kawanami
Gary Michael Xander
Moteto Mogi
Robert Sun
Application Number:
JP2012512347A
Publication Date:
April 09, 2014
Filing Date:
May 26, 2010
Export Citation:
Assignee:
Novartis Age
International Classes:
C07C233/87; A61K31/166; A61K31/33; A61K31/341; A61K31/351; A61K31/381; A61K31/40; A61K31/401; A61K31/4045; A61K31/41; A61K31/415; A61K31/4152; A61K31/4164; A61K31/4192; A61K31/4196; A61K31/42; A61K31/421; A61K31/4245; A61K31/428; A61K31/433; A61K31/4409; A61K31/4412; A61K31/445; A61K31/50; A61K31/505; A61P1/00; A61P3/04; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P11/06; A61P13/02; A61P13/12; A61P15/00; A61P15/04; A61P15/08; A61P17/00; A61P17/02; A61P25/04; A61P25/08; A61P25/20; A61P25/24; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P29/00; A61P31/02; A61P35/02; A61P43/00; C07C233/47; C07C233/48; C07C233/51; C07C233/63; C07C235/12; C07C235/34; C07C235/52; C07C235/60; C07C275/24; C07C311/19; C07C317/44; C07D207/16; C07D207/34; C07D209/18; C07D211/62; C07D213/56; C07D213/82; C07D231/14; C07D231/20; C07D233/64; C07D233/90; C07D237/14; C07D239/28; C07D249/10; C07D249/12; C07D249/18; C07D257/04; C07D261/10; C07D261/12; C07D263/34; C07D263/38; C07D271/06; C07D271/10; C07D275/06; C07D277/20; C07D277/56; C07D277/64; C07D285/12; C07D307/56; C07D309/38; C07D333/24; C07D333/40
Foreign References:
| US5217996 |
Other References:
Ksander, Gary M. et al.,Dicarboxylic Acid Dipeptide Neutral Endopeptidase Inhibitors,Journal of Medicinal Chemistry ,1995年,38(10),1689-700
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai
Takuji Yamada
Michiko Matsutani
Mitsutaka Iwasaki
Yasushi Ochiai