Title:
置換(アリール、ヘテロアリール、アリールメチル又はヘテロアリールメチル)ヒドロキサム酸化合物
Document Type and Number:
Japanese Patent JP4358908
Kind Code:
B2
Abstract:
This invention is directed to compounds of formula I: wherein the variables are as described herein. Compounds within the scope of the present invention possess useful properties, more particularly pharmaceutical properties. They are especially useful for inhibiting the production or physiological effects of TNF in the treatment of a patient suffering from a disease state associated with a physiologically detrimental excess of tumor necrosis factor (TNF). Compounds within the scope of the present invention also inhibit cyclic AMP phosphodiesterase, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting cyclic AMP phosphodiesterase, such disease states including inflammatory and autoimmune diseases, in particular type IV cyclic AMP phosphodiesterase. Compounds within the scope of the present invention may also inhibit an MMP, and are useful in treating a disease state associated with pathological conditions that are modulated by inhibiting MMPs, such disease states involve tissue breakdown and those associated with a physiologically detrimental excess of TNF. The present invention is therefore also directed to the pharmaceutical use of the compounds, pharmaceutical compositions containing the compounds, intermediates leading thereto and methods for the preparation of the compounds and their intermediates.
Inventors:
Gronberg robert dee
Nine Schwander Kent W
Julic Steven W
McGeehan Gerrard M
Burns christopher jay
Condon Stephen M
Mauricette Matthew M
Salvino joseph em
Scortes Antony Sea
Ulric John W
Nine Schwander Kent W
Julic Steven W
McGeehan Gerrard M
Burns christopher jay
Condon Stephen M
Mauricette Matthew M
Salvino joseph em
Scortes Antony Sea
Ulric John W
Application Number:
JP52464297A
Publication Date:
November 04, 2009
Filing Date:
January 02, 1997
Export Citation:
Assignee:
Aventis Pharmaceuticals, Inc.
International Classes:
C07C317/44; A61K31/00; C07D333/24; A61K31/165; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/4035; A61K31/47; A61P3/00; A61P3/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/08; A61P25/28; A61P27/00; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P33/00; A61P33/06; A61P37/00; C07C215/08; C07C259/06; C07C323/60; C07C323/65; C07D209/48; C07D215/14; C07D317/56; C07D317/62; A61K31/095; A61P35/00; A61P43/00
Domestic Patent References:
| JP9249638A | ||||
| JP3200772A | ||||
| JP53103430A | ||||
| JP52144601A | ||||
| JP50160267A | ||||
| JP50121218A |
Foreign References:
| US4029812 | ||||
| US3994997 |
Other References:
Chemie, Biochemie, Biophysik, Biologie, 1966年, Vol.21, No.2, p.180-182
Przemysl Chemiczny, 1964年, Vol.43, No.5, p.260-262
Przemysl Chemiczny, 1964年, Vol.43, No.5, p.260-262
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Kenji Asai
Fumiaki Otsuka
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Kenji Asai