Title:
置換アリールスルホニルアミノメチルホスホン酸誘導体、その製法並びにI型及びII型糖尿病の治療におけるその使用
Document Type and Number:
Japanese Patent JP2010534706
Kind Code:
A
Abstract:
The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
Inventors:
Wagner Holger
Rank Corp Elf
Eckhart Matthias
Streiher Rüdiger
Shell Hikorina
Schuler Mets Anette
Pouch alexander
Rank Corp Elf
Eckhart Matthias
Streiher Rüdiger
Shell Hikorina
Schuler Mets Anette
Pouch alexander
Application Number:
JP2010518631A
Publication Date:
November 11, 2010
Filing Date:
July 25, 2008
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D209/40; A61K31/404; A61K31/4178; A61K31/426; A61K31/433; A61K31/4439; A61K31/497; A61K31/501; A61K31/506; A61K31/53; A61K31/5377; A61K31/541; A61K31/551; A61P3/10; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D413/14; C07D417/04; C07D417/14
Domestic Patent References:
| JP2010521515A | 2010-06-24 | |||
| JP2010518149A | 2010-05-27 | |||
| JP2007500164A | 2007-01-11 | |||
| JP2007500165A | 2007-01-11 | |||
| JP2007500166A | 2007-01-11 |
Foreign References:
| WO2004096237A2 | 2004-11-11 | |||
| WO2003022271A1 | 2003-03-20 |
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Shintani Masashi
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Shintani Masashi