Title:
SUBSTITUTED BENZENE HAVING NOS SYNTHETASE-INHIBITORY ACTION
Document Type and Number:
Japanese Patent JPH1095762
Kind Code:
A
Abstract:
To obtain the novel subject compound which has nitrogen monoxide synthetase inhibitory action and is useful for cerebrovascular disorder (cerebral apoplexy) and the like.
The objective compound is represented by formula I [R1 is a (substituted) lower alkyl, a lower alkenyl, a lower alkynyl; R2-R4 are each H, a (substituted) lower alkyl; Y1-Y4 are each H, a halogen, nitro, cyano; n and m are each 0 or 1], typically N-(3-aminomethylphenyl)methyl thioacetoamidine. In order to prepare the compound, for example, a substituted aniline represented by formula II is allowed to react with a substituted imidate of formula III (R6, is tert.-butyl, benzyl) to form a substituted amidine of formula IV followed by deprotection.
Inventors:
EMURA TAKESHI
KIMURA NOBUAKI
NAGAFUJI TOSHIAKI
KIMURA NOBUAKI
NAGAFUJI TOSHIAKI
Application Number:
JP14519797A
Publication Date:
April 14, 1998
Filing Date:
June 03, 1997
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
C07D295/14; A61K31/155; A61K31/34; A61K31/341; A61K31/38; A61K31/381; A61K31/40; A61K31/445; A61P3/08; A61P9/00; A61P13/02; A61P15/00; A61P25/00; A61P25/04; A61P25/28; A61P25/30; A61P29/00; A61P31/12; A61P37/00; A61P37/06; A61P43/00; C07C257/20; C07C323/52; C07D307/14; C07D333/22; (IPC1-7): C07C257/20; A61K31/155; A61K31/34; A61K31/38; A61K31/40; A61K31/445; C07C323/52; C07D295/14; C07D307/14; C07D333/22
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)