Title:
置換ベンゾジアゼピン誘導体
Document Type and Number:
Japanese Patent JP5117192
Kind Code:
B2
Abstract:
The present invention is concerned with a method of treating Alzheimer's disease by administering a therapeutically effective amount of a substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine of formula I wherein R1, R2, and R3 are as defined herein, and their pharmaceutically acceptable acid addition salts. The invention also provides novel compounds of formula I-A and pharmaceutical compositions containing them.
Inventors:
Nunst, Henner
Stadler, Heinz
Thomas, Andrew William
Stadler, Heinz
Thomas, Andrew William
Application Number:
JP2007536039A
Publication Date:
January 09, 2013
Filing Date:
October 04, 2005
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K31/5517; A61P25/22; A61P25/28; C07D487/04
Domestic Patent References:
| JP5202051A | ||||
| JP2004517070A |
Other References:
GERECKE MAX,HETEROCYCLES,NL,ELSEVIER SCIENCE PUBLISHERS B.V.,1994年,V39 N2,P693-721
J. Grayson Richards, et al.,Brain Research Bulletin,1998年,45(4),381-387頁
J. Grayson Richards, et al.,Brain Research Bulletin,1998年,45(4),381-387頁
Attorney, Agent or Firm:
Patent business corporation Tsukuni
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Atsushi Shiomi
Fusayuki Saito
Hajime Tsukuni
Yasuo Yanagibashi
Satoko Ito
Keiko Ozawa
Toshio Miyake
Yasuhiro Oguni
Yoko Tanaka
Yoshinori Ikukawa
Akio Shibata
Atsushi Shiomi
Fusayuki Saito