Title:
ナトリウムチャネル遮断薬としての置換ベンゾジアゼピノン、ベンゾオキサアゼピノン及びベンゾチアゼピノン
Document Type and Number:
Japanese Patent JP2010520237
Kind Code:
A
Abstract:
The present invention is directed to substituted benzodiazepinones, benzoxazepinones and benzothiazepinones compounds that are sodium channel blockers useful for the treatment of chronic and neuropathic pain. The compounds of the present invention are also useful for the treatment of other conditions, including disorders of the CNS such as anxiety, depression, epilepsy, manic depression and bipolar disorder. This invention also provides pharmaceutical compositions comprising a compound of the present invention, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. This invention further comprises methods for the treatment of acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain and disorders of the CNS including, but not limited to, epilepsy, manic depression, depression, anxiety and bipolar disorder comprising administering the compounds and pharmaceutical compositions of the present invention.
Inventors:
Hoyt, Scott Bee
Okay don
Okay, Hyeon Oh
London, Clare
Duffy, Joseph El
Okay don
Okay, Hyeon Oh
London, Clare
Duffy, Joseph El
Application Number:
JP2009551993A
Publication Date:
June 10, 2010
Filing Date:
February 25, 2008
Export Citation:
Assignee:
Merck Sharp End Dome Corporation
International Classes:
C07D267/14; A61K31/551; A61K31/553; A61K31/554; A61K45/00; A61P3/10; A61P3/12; A61P13/02; A61P17/00; A61P19/02; A61P25/00; A61P25/04; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P29/00; A61P29/02; A61P31/18; A61P31/22; A61P43/00; C07D243/12; C07D281/10
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura