置換ベンゾイルグアニジン、その製造方法、医薬または診断薬としてのその使用およびそれを含有する医薬

Japanese Patent JP4880849

B2

Benzoylguanidine derivatives (I) and their salts are new. Benzoylguanidine derivatives of formula (I) and their salts are new. [Image] R 1H, halo, NO 2, CN, (X) o-(CH 2) p-(CF 2) q-CF 3, SO m-R 5, COR 6, CONR 6R 7 or SO 2-NR 6R 7; R 3H, halo, NO 2, CN, (X) o-(CH 2) p-(CF 2) q-CF 3, SO m-R 5, COR 6, CONR 6R 7, SO 2-NR 6R 7, 1-6C alkyl or X-R 1 3; X : O, S or NR 1 4; m, p : 0-2; o : 0 or 1; q : 0-6; R 51-8C alkyl, 3-6C alkenyl, (CH 2) n-R 8 or CF 3; R 6H, 1-8C alkyl, 3-6C alkenyl, (CH 2) n-R 8 or CF 3; R 7H or 1-4C alkyl; n : 0-4; R 83-7C cycloalkyl or phenyl (optionally substituted by 1-3 F, Cl, CF 3, CH 3, OCH 3 or NR 9R 1 0 groups); R 2Y-Q; Q : phenyl substituted by heteroaryl which is optionally substituted by 1-3 F, Cl, CF 3, CH 3, OCH 3, OH, NH 2, NHCH 3, N(CH 3) 2 or benzyl groups; Y : O, S or NR 1 2; R 1 2H or 1-4C alkyl; R 1 4H or 1-3C alkyl; R 1 3H, 1-6C alkyl, 3-8C cycloalkyl or (CH 2) b-R 1 5; R 4halo or 1-4C alkyl; b : 0-4; and R 1 5optionally substituted phenyl; or R 6+R 7 or R 1 3+R 1 4 together : (CH 2) 4 or (CH 2) 5, where a CH 2 group can be replaced by S, S, NH, NCH 3 or N-benzyl. - ACTIVITY : Vasotropic; cardiant; antiarrhythmic; antianginal; cerebroprotective; antiallergic; antibacterial; immunosuppressive; antiarteriosclerotic; antidiabetic; cytostatic; hypotensive; anticoagulant; thrombolytic; antilipemic - MECHANISM OF ACTION : Sodium antagonist; vasodilator; LDL antagonist; VLDL antagonist

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Andreas Weichert
Oud Arbus
Hans-Villi Janssen
Heinz-Werner Klemann
Hans-Jochen Lang

JP2001553261A

February 22, 2012

January 08, 2001

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Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung

A61K31/4164; C07D233/60; A61K31/4196; C07D249/08; A61P1/16; A61P3/00; A61P3/10; A61P9/06; A61P9/10; A61P11/00; A61P13/12; A61P15/00; A61P25/00; A61P35/00; A61P41/00; C07D233/64; C07D521/00

JPH0873427A	1996-03-19
JPH069545A	1994-01-18
JPH0789938A	1995-04-04
JPH1067733A	1998-03-10
JPH1081662A	1998-03-31
JPH107644A	1998-01-13
JPH07109251A	1995-04-25

Junji Yuda
Noriyuki Takebayashi
Chika Takagi
Kosuke Nishimura

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