Title:
SUBSTITUTED CYCLIC AMINE COMPOUND, ITS PRODUCTION AND MEDICINE FOR CIRCULATORY ORGAN CONTAINING THE SAME COMPOUND
Document Type and Number:
Japanese Patent JP3836892
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new substituted cyclic amine compound having a strong and selective serotonin 2 receptor antagonistic effect and useful for prevention and therapy of hypertension, ischemic heart diseases, cerebrovascular diseases, etc.
CONSTITUTION: A compound is expressed by formula I [A is CONR4 or SO2NR4 (R4 is an alkyl, an alkenyl, an aralkyl, an acyl, phenyl, naphthyl, etc.); B is a single bond, CHOH or CO; D is CH, H or N(0); Q is CH or N; R1 and R2 are H, a halogen, an alkyl, an alkenyl, an alkoxy, a hydroxyalkyl, an alkyl- substituted or non-substituted amino, an acylamino, an amidino which may be substituted, a (thio)ureido which may be substituted, an azole, a carboxyl, formyl, etc.; R3 is H, a halogen, a mono- or di-alkylamino; (n) is 2 to 6] or its salt, e.g. N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-3-methoxy-N-(2- methoxyphenyl)benzamide oxalic acid salt. This compound can be synthesized by reacting a compound of formula II with a compound of formula III.
Inventors:
Takeshi Aoki
Atsushi Takahashi
Hiroyasu Sato
Eiji Shimanuki
Gengo
Nishiki Touki
Shoko Ishigami
Shinichi Yamada
Takahiro Yamaguchi
Yoichi Mame
Isamu Sato
Kentaro Furushiro
Senichi Narita
Atsushi Takahashi
Hiroyasu Sato
Eiji Shimanuki
Gengo
Nishiki Touki
Shoko Ishigami
Shinichi Yamada
Takahiro Yamaguchi
Yoichi Mame
Isamu Sato
Kentaro Furushiro
Senichi Narita
Application Number:
JP33670794A
Publication Date:
October 25, 2006
Filing Date:
December 26, 1994
Export Citation:
Assignee:
Toa Seiyo Co., Ltd.
International Classes:
C07D211/32; C07D295/12; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4427; A61K31/443; A61K31/445; A61K31/451; A61K31/4525; A61K31/453; A61K31/454; A61K31/4545; A61K31/495; A61K31/5377; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P43/00; C07C69/612; C07C233/66; C07C233/69; C07C235/46; C07C235/48; C07C237/30; C07C237/32; C07C237/42; C07C251/48; C07C255/57; C07C257/18; C07C271/20; C07C309/65; C07C309/66; C07C311/13; C07C311/15; C07C323/42; C07D211/18; C07D211/22; C07D211/26; C07D213/71; C07D213/81; C07D401/06; C07D401/12; C07D405/12; C07D417/12; (IPC1-7): C07D211/32; A61K31/44; A61K31/445; A61K31/495; A61K31/495; C07C233/66; C07C233/69; C07C235/46; C07C235/48; C07C237/30; C07C237/32; C07C237/42; C07C251/48; C07C255/57; C07C257/18; C07C271/20; C07C309/65; C07C309/66; C07C311/13; C07C311/15; C07C323/42; C07D211/18; C07D211/22; C07D211/26; C07D213/71; C07D213/81; C07D295/12; C07D401/06; C07D401/06; C07D401/12; C07D401/12; C07D405/12; //C07C69/612
Domestic Patent References:
JP1100149A | ||||
JP59186959A | ||||
JP55105679A | ||||
JP39021828B1 | ||||
JP5148233A | ||||
JP50131929A |
Foreign References:
WO1988002365A1 | ||||
US2794804 | ||||
GB2159815A |
Other References:
J.Med.Chem.,1992年,Vol.35, No.26,p.4903-4910
J.Med.Chem.,1988年,Vol.31, No.10,p.1968-1971
Biochimica et Biophysica Acta,1991年,Vol.1073,p.33-42
Journal of Organometallic Chemistry,1991年,Vol.417,p.253-276
J.Med.Chem.,1988年,Vol.31, No.10,p.1968-1971
Biochimica et Biophysica Acta,1991年,Vol.1073,p.33-42
Journal of Organometallic Chemistry,1991年,Vol.417,p.253-276
Attorney, Agent or Firm:
Nobuo Kawakami
Toshio Yoshizawa
Junichi Takahashi
Toshio Yoshizawa
Junichi Takahashi
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