Title:
置換ヘテロアリールのCB1拮抗薬
Document Type and Number:
Japanese Patent JP2008536950
Kind Code:
A
Abstract:
Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the treatment of conditions responsive to CB1 modulation in humans, domesticated companion animals and livestock animals, including appetite disorders, obesity and addictive disorders. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies and various in vitro assays.
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Inventors:
Yuan, Jun
Kuo, Chin
Chao, Ho
Fu, Xiao Jin
White House, Darren
Fringle, wallace
Mao, Jiang Min
Maynard, George
Hummer, jack
Wustrow, david
Lee, Hong Bin
Kuo, Chin
Chao, Ho
Fu, Xiao Jin
White House, Darren
Fringle, wallace
Mao, Jiang Min
Maynard, George
Hummer, jack
Wustrow, david
Lee, Hong Bin
Application Number:
JP2008511130A
Publication Date:
September 11, 2008
Filing Date:
April 18, 2006
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
C07D241/18; A61K9/06; A61K9/08; A61K9/12; A61K9/20; A61K9/48; A61K9/70; A61K31/4965; A61K31/497; A61K31/506; A61K31/53; A61K31/5377; A61K31/541; A61K51/00; A61P1/04; A61P1/16; A61P3/00; A61P3/04; A61P11/06; A61P19/10; A61P25/02; A61P25/18; A61P25/24; A61P25/28; A61P31/04; C07D241/20; C07D241/24; C07D401/04; C07D401/12; C07D401/14; C07D403/14; C07D405/12; C07D417/12
Attorney, Agent or Firm:
Norio Saeki