SUBSTITUTED HYDROXYLAMINE

Title:

SUBSTITUTED HYDROXYLAMINE

Document Type and Number:

Japanese Patent JPH01165554

Kind Code:

A

Abstract:

NEW MATERIAL: A compound of formula I [R is H, ester or cation; R1 is formula II or III (R2 is H, halogen, 1-6C alkyl; A is halogen, alkyl, alkoxy, aryl, etc.; B is cycloalkyl, halogen, cyano, alkoxy, etc.), etc.].

EXAMPLE: N-[2-[3-(4-fluoroshenyl)-1,5-diisopropyl-2-phenylpyrol-4-yl]ethyl] hydroxylamine.

USE: 3-Hydroxy-3-methyl-gultaryl coenzyme Ainhibitor and cholesterol biosynthesis inhibitor. Useful for treatment of hyperproteinemia and atherosclerosis.

PROCESS: A compound of formula I is obtained by allowing a hydroxylamine of formula of R1-CH2CH2-NH to react with an epoxide of formula IV (R7 is 1-6C alkyl) in an alcohol solvent at 0 to 150°C.

More Like This:

WO/2000/067744	NEUROPROTECTIVE COMPOSITION AND USES THEREOF
JP2005060397	PYRUVATE ENRICHED ONION EXTRACT
WO/2018/049216	MONOMERIC BIMETAL HYDROXYCITRIC ACID COMPOUNDS AND METHODS OF MAKING AND USING THE SAME

Inventors:

BARUTAA HIYUPUSHIYU
RORUFU ANGAABAUAA
PEETAA FUAI
HIRUMARU BISHIYOTSUFU
DEIITAA PETSUTSUINA
DERUFU SHIYUMITSUTO

Application Number:

JP29373788A

Publication Date:

June 29, 1989

Filing Date:

November 22, 1988

Export Citation:

Click for automatic bibliography generation Help

Assignee:

BAYER AG

International Classes:

A61K31/19; A61K31/22; A61K31/34; A61K31/341; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61P3/06; A61P9/10; C07C45/00; C07C49/235; C07C67/00; C07C69/738; C07C201/00; C07C205/45; C07C239/00; C07C239/18; C07C313/00; C07C317/30; C07C317/32; C07C323/36; C07D521/00; C07C323/37; C07C323/47; C07D207/335; C07D207/34; C07D207/36; C07D209/14; C07D209/18; C07D231/12; C07D307/42; C07D307/46; C07D307/52; C07D307/68; C07D333/20; C07D207/32; (IPC1-7): A61K31/19; A61K31/22; A61K31/34; A61K31/38; A61K31/40; A61K31/415; C07C49/235; C07C69/738; C07C79/36; C07C83/08; C07C147/12; C07C149/42; C07D207/335; C07D207/34; C07D207/36; C07D209/14; C07D209/18; C07D231/12; C07D307/42; C07D307/46; C07D307/52; C07D307/68; C07D333/20; C07D521/00

Attorney, Agent or Firm:

Heikichi Odashima

Previous Patent: PRODUCTION OF NOVEL FLUORINATED NITROALKYL COMPOUND, AND NOVEL AND KNOWN FLUORINATED NITROALKYL COMP...

Next Patent: JPH01165555