Title:
置換されたイミダゾリジン、その製造方法、その医薬又は診断薬としての使用、及び、置換されたイミダゾリジンを含有する医薬
Document Type and Number:
Japanese Patent JP4571803
Kind Code:
B2
Abstract:
The invention relates to new imidazolidine-type compounds of formula (I) in which R1 to R7 have the meanings disclosed in the claims. Said compounds represent potent inhibitors of sodium/hydrogen exchanger (NHE), particularly NHE. These novel compounds are used to produce a drug for the therapy or prophylaxis of the central nervous system, lipometabolism, infestations by ectoparasites, dysfunctions of the gall and for improving respiratory drive. The inventive compounds are therefore used for the therapy of respiratory conditions in the following clinical states and diseases: malfunctioning central respiratory drive (e.g. sleep apnoea, sudden infant death, postoperative hypoxia), muscle-related breathing disturbances, breathing disturbances following long-term respiration, breathing disturbances when adapting to high mountain areas, obstructive sleep apnoea and a mixed type of sleep apnoea, acute and chronic lung diseases with hypoxia and hypercapnia. Said compounds also increase the muscle tone in the upper respiratory tract so as to suppress snoring.
Inventors:
Uwe Heinert
Hans-Jochen Lang
Armin Hofmeister
Klaus Wild
Hans-Jochen Lang
Armin Hofmeister
Klaus Wild
Application Number:
JP2003554191A
Publication Date:
October 27, 2010
Filing Date:
December 09, 2002
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07D233/06; A61K31/4168; A61K31/4184; A61P1/00; A61P1/16; A61P3/06; A61P9/10; A61P11/00; A61P13/12; A61P25/00; A61P25/02; A61P33/00; A61P33/14; A61P43/00; C07D233/50; C07D235/02; C07D235/30
Domestic Patent References:
| JP10109970A | ||||
| JP7145149A | ||||
| JP2001526638A |
Foreign References:
| WO2002046169A1 | ||||
| DE19960204A1 | ||||
| WO2001079186A1 | ||||
| WO2001021582A1 | ||||
| WO2001072742A1 | ||||
| WO2001030761A1 |
Other References:
Am. J. Physiol. Cell Physiol.,2000年,vol.279,pp.1918-1924
Am. J. Physiol. Cell Physiol.,1999年,vol.276,pp.136-144
J. Biol. Chem. ,1993年,vol.268,pp.25536-25541
Eur. J. Pharmacol.,1987年,vol.134,pp.1-13
Circulation Research, Supplement ,1980年,46(1),pp.15-20
Am. J. Physiol. Cell Physiol.,1999年,vol.276,pp.136-144
J. Biol. Chem. ,1993年,vol.268,pp.25536-25541
Eur. J. Pharmacol.,1987年,vol.134,pp.1-13
Circulation Research, Supplement ,1980年,46(1),pp.15-20
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi