Title:
置換イミダゾロピラジンおよびトリアゾロピラジン誘導体類:GABAAレセプタリガンド類
Document Type and Number:
Japanese Patent JP2007501272
Kind Code:
A
Abstract:
Compounds of Formula (1) are provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8, and Ar in the above Formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).
Inventors:
Z Yuelian
Humming song
Sailing Hung
Humming song
Sailing Hung
Application Number:
JP2006532554A
Publication Date:
January 25, 2007
Filing Date:
May 03, 2004
Export Citation:
Assignee:
Neurogen Corporation
Z Yuelian
Humming song
Sailing Hung
Z Yuelian
Humming song
Sailing Hung
International Classes:
C07D487/04; A61K31/4985; A61K51/00; A61P17/00; A61P25/00; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/36; A61P43/00; C07D519/00; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Kenji Yoshida
Jun Ishida
Jun Ishida