Title:
BACE阻害剤としての置換イソインドール類及びそれらの使用
Document Type and Number:
Japanese Patent JP2012508734
Kind Code:
A
Abstract:
The present invention relates to novel compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Downs syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer Disease, memory loss, attention deficit symptoms associated with Alzheimer disease, neurodegeneration associated with diseases such as Alzheimer disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
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Inventors:
Jörg Horenz
Sophia Karlstrom
Karin Kormodin
Johann Lindström
Lathro Racos
Didier Lottissi
Peter Sodermann
Brit-Marie Svern
Stephan von Berg
Sophia Karlstrom
Karin Kormodin
Johann Lindström
Lathro Racos
Didier Lottissi
Peter Sodermann
Brit-Marie Svern
Stephan von Berg
Application Number:
JP2011536289A
Publication Date:
April 12, 2012
Filing Date:
November 13, 2009
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
C07D401/04; A61K31/4439; A61K31/444; A61K31/497; A61K31/506; A61P9/00; A61P25/00; A61P25/28; A61P43/00; C07D401/14; C07D403/10
Domestic Patent References:
| JP2008526966A | 2008-07-24 |
Foreign References:
| WO2007149033A1 | 2007-12-27 |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi