Title:
痛みを治療するためのバニロイド-1受容体アンタゴニストとしての、置換された含窒素六員アミノ複素環
Document Type and Number:
Japanese Patent JP2007510706
Kind Code:
A
Abstract:
The present invention provides a compound of formula(I): Y-J-NH-Z (I) wherein: Y is a quinoline or isoquinoline optionally substituted with one or two substituents independently chosen from halogen, haloC1-4 alkyl, C1-4alkyl, C1-4 alkoxy, haloC1-4 alkoxy, nitro and amino; J is pyridine, pyridazine, pyrazine, pyrimidine or triazine optionally substituted with one or two substituents independently chosen from halogen, haloC1-4 alkyl, C1-4alkyl, C3-5 cycloalkyl, C1-4 alkoxy, haloC1-4 alkoxy, nitro and amino; wherein J is substituted at positions meta to each other by NH and Y; and Z is phenyl or pyridyl optionally substituted with one or two substituents independently elected from halogen, haloC1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, haloC1-4 alkoxy, nitro and amino; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions containing the same; the compound for use in therapy; and use of the compound for the manufacture of a medicament for treating or preventing diseases requiring administration of an antagonist of the vanilloid-1 (VR1) receptor.
Inventors:
Holingworth, Gregory Jiyoung
Brian Aye, The Jones
McIver, Edward Jills
Moise, Christopher Richard
Rogers, Rogers
Brian Aye, The Jones
McIver, Edward Jills
Moise, Christopher Richard
Rogers, Rogers
Application Number:
JP2006538935A
Publication Date:
April 26, 2007
Filing Date:
November 09, 2004
Export Citation:
Assignee:
Merck Sharp End Dome Limited
International Classes:
C07D401/04; A61K31/497; A61K31/498; A61K31/506; A61K31/5377; A61K31/55; A61P11/14; A61P25/04; A61P25/24; C07D401/14; C07D403/04; C07D471/04
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura