PURPOSE: To obtain a new compound useful as an excellent antitumor agent.
CONSTITUTION: A compound shown by formula I [X1 and X2 are O, S(O)n ((n) is 0-2), N(R3) (R3 is lower hydrocarbon) or methylene; Y 18 NH-C (=Z)-NH (Z is O or S), N=C(Z')-NH (Z' is halogen, etc.); Ar is phenyl; one of R1 and R2 is H and the other is lower hydrocarbon or R1 and R2 together with C form 3- to 8-membered ring] such as 1-[3,4-(dimethylmethylenedioxy) benzenesulfonyl]-3-(4-chlorophenyl)urea. The compound shown by formula I is obtained by reacting a compound shown by formula II (Y' is N=C=Z, NH2, etc.) with a compound shown by the formula Y"-Ar (Y" is H2N, Z=C=N, etc.) in a solvent (e.g. acetone) in the presence of a base (e.g. NaOH) at 0°C to the boiling temperature of the solvent.
OTSU KOICHIRO
ITO FUMIO
