Title:
薬剤として用いるための置換ピラジノン誘導体
Document Type and Number:
Japanese Patent JP2010505908
Kind Code:
A
Abstract:
The present invention concerns substituted pyrazinone derivatives according to the general Formula (I) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, an N-oxide form thereof or a quaternary ammonium salt thereof, wherein the variables are defined in claim 1, having selective 2C-adrenoceptor antagonist activity. It further relates to their preparation, compositions comprising them and their use as a medicine. The compounds according to the invention are useful for the prevention and/or treatment of central nervous system disorders, mood disorders, anxiety disorders, stress-related disorders associated with depression and/or anxiety, cognitive disorders, personality disorders, schizoaffective disorders, Parkinson's disease, dementia of the Alzheimer's type, chronic pain conditions, neurodegenerative diseases, addiction disorders, mood disorders and sexual dysfunction.
Inventors:
Andre Jill, Jose Ignacio
Alcazar-Baka, Manuel Jesuits
Linares de la Morena, Maria Rawdes
Martinez Gonzalez, Sonia
Oyarzabal Santa Marina, Jiullen
Pastor-Fernandez, Joaquin
Vega-Ramiro, Juan Antonio
Delgado-Jimenes, Francisca
Drinkenburg, Wilhelms Helena Ignatius Maria
Alcazar-Baka, Manuel Jesuits
Linares de la Morena, Maria Rawdes
Martinez Gonzalez, Sonia
Oyarzabal Santa Marina, Jiullen
Pastor-Fernandez, Joaquin
Vega-Ramiro, Juan Antonio
Delgado-Jimenes, Francisca
Drinkenburg, Wilhelms Helena Ignatius Maria
Application Number:
JP2009531832A
Publication Date:
February 25, 2010
Filing Date:
October 10, 2007
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D241/20; A61K31/497; A61K45/00; A61P15/10; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/32; A61P25/34; A61P25/36; A61P43/00; C07D401/04; C07D401/12; C07D401/14; C07D403/06; C07D405/06; C07D405/14; C07D409/06; C07D413/06
Attorney, Agent or Firm:
Patent business corporation Odashima patent office