Title:
過剰増殖性疾患の治療のための置換ピラゾール化合物およびそれらの使用方法
Document Type and Number:
Japanese Patent JP7373992
Kind Code:
B2
Abstract:
Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulaeandin which R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.
Inventors:
Arshad, M. Sidiki
Stefan, Sibrat
Martin, Delhi
Rhea, Constantino-Forget
Chantal, Gran-meter
Nicolas, Bruno-Latour
Gerald W. Ships
Alan, B. Cooper
Viva, Oza
Matthew, Taburu Costura
Michael luther
Jed, Levine
Stefan, Sibrat
Martin, Delhi
Rhea, Constantino-Forget
Chantal, Gran-meter
Nicolas, Bruno-Latour
Gerald W. Ships
Alan, B. Cooper
Viva, Oza
Matthew, Taburu Costura
Michael luther
Jed, Levine
Application Number:
JP2019528861A
Publication Date:
November 06, 2023
Filing Date:
November 29, 2017
Export Citation:
Assignee:
BANTAM PHARMACEUTICAL, LLC
International Classes:
C07D417/04; A61K31/4196; A61K31/427; A61K31/433; A61K31/438; A61K31/454; A61K31/46; A61K31/496; A61K31/497; A61K31/5377; A61P35/00; A61P35/02; A61P43/00; C07D417/14; C07D451/06
Domestic Patent References:
| JP6707630B2 | ||||
| JP2020513403A | ||||
| JP2015534990A | ||||
| JP2006522164A |
Foreign References:
| WO2015144290A1 |
Attorney, Agent or Firm:
Hiroyuki Nagai
Yukitaka Nakamura
Satoru Asakura
Mari Asano
Hiroshi Sorimachi
Hiroyuki Fujii
Yukitaka Nakamura
Satoru Asakura
Mari Asano
Hiroshi Sorimachi
Hiroyuki Fujii
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