Title:
ＰＤＥ４阻害剤としての置換ピリジン及びピラジン化合物
Document Type and Number:
Japanese Patent JP6505878
Kind Code:
B2
Abstract:
The invention provides a chemical entity of Formula (I), and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders.
Inventors:
Venkateir Volu
James Breitenbusher
Alan Caplan
Robert Rems
Andrew Lindstrom
Troy Vickers
Mark E. Wilson
James Zappow
Michael i wine house
James Breitenbusher
Alan Caplan
Robert Rems
Andrew Lindstrom
Troy Vickers
Mark E. Wilson
James Zappow
Michael i wine house
Application Number:
JP2018009464A
Publication Date:
April 24, 2019
Filing Date:
January 24, 2018
Export Citation:
Assignee:
Dirt Neuroscience (Cayman) Limited
International Classes:
A61P43/00; A61K31/4418; A61K31/4427; A61K31/4439; A61K31/444; A61K31/4965; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K49/00; A61K51/04; A61P1/04; A61P7/00; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P29/00; A61P35/00; A61P37/08
Domestic Patent References:
| JP6282721B2 | ||||
| JP2011505341A | ||||
| JP2010505789A | ||||
| JP2013540145A |
Foreign References:
| WO2007123953A1 | ||||
| WO1999031062A1 | ||||
| KR1020060001207A | ||||
| WO2006124874A1 |
Other References:
Nature Biotechnology,2010年,Vol.28(1),p.63-70
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe