Title:
SUBSTITUTED PYRROLIDINE DERIVATIVE AND HIV PROTEASE INHIBITOR
Document Type and Number:
Japanese Patent JP3198191
Kind Code:
B2
Abstract:
PURPOSE: To obtain compounds having inhibiting activity of human immunodeficiency virus protease, which are useful in the treatment of HIV infections.
CONSTITUTION: Compounds of formula I [X is an R2OD(O), R2NR3C(O) or the like; R2 is a lower alkyl, phenyl or the like; R3 is H or a lower alkyl; R1 is a lower alkyl or lower cycloalkyl; Y is a lower alkyl, lower cycloalkyl, phenyl or the like; B is absent or a divalent group -NHCHR4C(O)-; R4 is a lower alkyl or the like], such as 4(S)-benzyloxy-1{3(S)-{{N-(benbyloxyloxycarbonyl)- valyl}amino}-2(R)-hydroxy-4-phenylbutyl}-N-tert-butylpyrrolidine-2(S)- carboxamide. The compd. of the formula I is obtained by reacting an epoxide of the formula II with pyrrolidinecarboxamide of formula III.
Inventors:
Vida Gorlis
Francois suzie
Christian Joachim
Pierre Louis Beaulieu
Francois suzie
Christian Joachim
Pierre Louis Beaulieu
Application Number:
JP5414193A
Publication Date:
August 13, 2001
Filing Date:
March 15, 1993
Export Citation:
Assignee:
Boehringer Ingelheim (Canada) Limited
International Classes:
A61K31/44; A61K31/4427; A61K31/505; A61P31/12; A61P31/18; A61P43/00; C07D207/16; C07D401/12; A61K31/40; C07D401/14; C07D403/12; (IPC1-7): C07D207/16; A61K31/40; A61K31/44; A61K31/505; A61P31/18; A61P43/00; C07D401/12; C07D403/12
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)