Title:
ｃＦＭＳ阻害剤としての置換Ｎ−（１Ｈ−インダゾール−４−イル）イミダゾ［１，２−ａ］ピリジン−３−カルボキサミド化合物
Document Type and Number:
Japanese Patent JP5739448
Kind Code:
B2
Abstract:
Compounds of Formula (I): and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4 and R5 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases and pain.
Inventors:
Voice, mark lawrence
Bradley, Michael F.
Delile, Robert Kirk
Hennings, Dee. David
Kennedy, April L.
Mam Sutter, Frederick Pee.
Medina, matthew david
Manson, Mark See.
Last, bryson
Ritzy, James P.
Rodriguez, Martha E.
Toparov, George Tee.
Chao, Chiang
Bradley, Michael F.
Delile, Robert Kirk
Hennings, Dee. David
Kennedy, April L.
Mam Sutter, Frederick Pee.
Medina, matthew david
Manson, Mark See.
Last, bryson
Ritzy, James P.
Rodriguez, Martha E.
Toparov, George Tee.
Chao, Chiang
Application Number:
JP2012546120A
Publication Date:
June 24, 2015
Filing Date:
December 20, 2010
Export Citation:
Assignee:
VentiRx Pharmaceuticals,Inc.
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4545; A61K31/496; A61K31/4985; A61K31/4995; A61K31/506; A61K31/5377; A61K31/5386; A61K31/541; A61K31/551; A61P9/00; A61P19/08; A61P25/04; A61P29/00; A61P35/00; A61P37/02; C07D519/00
Domestic Patent References:
| JP2008545652A |
Foreign References:
| WO2008124323A1 | ||||
| WO2009147189A1 | ||||
| WO2009112679A1 |
Other References:
SMALLEY,T.L. et al.,Synthesis of novel anilinoquinolines as c-fms inhibitors,Bioorganic & Medicinal Chemistry Letters,2007年,17(22),6257-6260
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita