Title:
ウルソデオキシコール酸の硫酸コンジュゲートと、炎症性障害及び他の用途におけるそれらの有利な使用
Document Type and Number:
Japanese Patent JP4630195
Kind Code:
B2
Abstract:
One aspect of this invention is directed to a pharmacologically acceptable composition including a sulfate of 3 alpha, 7 beta-dihydroxy-5 beta-cholan-24-oic acid (Ursodeoxycholic acid or "UDCA") and a pharmacologically acceptable carrier. In a preferred composition, the sulfate is UDCA-3-sulfate, UDCA-7-sulfate, UDCA-3,7-disulfate, glyco-UDCA-3-sulfate, glyco-UDCA-7-sulfate, glyco-UDCA-3,7-disulfate, tauro-UDCA-3-sulfate, tauro-UDCA-7-sulfate, tauro-UDCA-3,7-disulfate or a combinations thereof. Another aspect of the invention concerns a method of delivering UDCA to a mammal to inhibit or treat a disorder, which includes administering a sulfate of UDCA to the mammal in an amount sufficient to inhibit or treat the disorder. For example, a UDCA sulfate may be used to advantage in inhibiting or treating an inflammatory condition of the gastrointestinal tract, such as colon cancer, rectum cancer, a neoplasm of the colon, a neoplasm of the rectum, carcinogenesis of the colon, carcinogenesis of the rectum, ulcerative colitis, an adenomatous polyp, familial polyposis and the like. A sulfate of UDCA also may be administered to inhibit or treat an inflammatory disorder of the liver. A UDCA sulfate may be used to improve serum biochemistries of liver disease or liver function, to increase bile flow or to decrease biliary secretion of phospholipid or cholesterol. In yet a further aspect, the invention is directed to a method of maintaining an isolated organ by perfusing the organ with a sulfate of UDCA.
Inventors:
Sechel, Kenneth, Day., Earl
Application Number:
JP2006003753A
Publication Date:
February 09, 2011
Filing Date:
January 11, 2006
Export Citation:
Assignee:
Children's Hospital Medical Center
International Classes:
A61K31/575; A61K47/24; A61K31/00; A61P1/00; A61P1/04; A61P1/16; A61P35/00
Domestic Patent References:
| JP59163400A |
Other References:
H.TAKIKAWA ET AL,J.HEPATOL.,1992年 5月,vol.15,no.1-2,77-84
H.TAKIKAWA ET AL.,J.HEPATOL.,1993年,vol.17,no.2,247-252
JAPAN DRUGS 日本医薬品総覧 1994年版,株式会社メディカルレビュー社,1994年 2月15日,192-193
BANDIERA,T. et al,A convenient procedure for the synthesis of ursodeoxycholic acid sulfated derivatives.,Synth Commun,1987年,Vol.17, No.9,p.1111-1117
H.TAKIKAWA ET AL.,J.HEPATOL.,1993年,vol.17,no.2,247-252
JAPAN DRUGS 日本医薬品総覧 1994年版,株式会社メディカルレビュー社,1994年 2月15日,192-193
BANDIERA,T. et al,A convenient procedure for the synthesis of ursodeoxycholic acid sulfated derivatives.,Synth Commun,1987年,Vol.17, No.9,p.1111-1117
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Kajiwara Saiko
Yukihiro Ikeda
Hajime Asamura
Kajiwara Saiko
Yukihiro Ikeda