Title:
スルフィニルフェニル又はスルホンイミドイルフェニルベンザゼピン
Document Type and Number:
Japanese Patent JP6893501
Kind Code:
B2
Abstract:
This invention relates to novel sulfinylphenyl or sulfonimidoylphenyl benzazepine compounds of the formula (I) wherein X and R1 to R6 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.
Inventors:
Hove's, Sabine
Wan, Leisher
Yun, Hong Yin
Chan, Weishin
Chu, Way
Wan, Leisher
Yun, Hong Yin
Chan, Weishin
Chu, Way
Application Number:
JP2018513622A
Publication Date:
June 23, 2021
Filing Date:
September 14, 2016
Export Citation:
Assignee:
Ef Hoffman-La Roche Akchengezel Shaft
International Classes:
C07D223/16; A61K31/55; A61P11/06; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/04; A61P37/06; A61P37/08; A61P43/00; B01J31/24; C07D401/04
Domestic Patent References:
| JP2013502431A | ||||
| JP2013502430A | ||||
| JP2014505692A | ||||
| JP2009504763A |
Foreign References:
| WO2009059047A2 |
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation