SULFONAMIDE DERIVATIVE

Japanese Patent JP2000319250

A

To obtain a new compound which has a strong matrix metalloproteinase-13 (collagenase-3)-inhibiting activity and a strong aggrecanase- inhibiting activity.

A compound of formula I [R1 is OH or hydroxyamino; R2 is H, a 3 to 7C cycloalkyl or the like; R3 is H, a (substituted) lower alkyl or the like; R4 is a (substituted)arylene, a (substituted) heteroarylene; R5 is a (substituted) lower alkyl, a (substituted) aryl or the like; but when R2 is H, a (substituted) lower alkyl or the like; R3 is a (substituted)alkynyl], for example, (±)-N-hydroxyl-Nα-(4-methoxybenzene sulfonyl)-2-[2-(quinazoline-2,4-dion-3-yl) ethyl]glycinamide. The compound of formula I is produced, for example, by reacting a compound of formula II (G1 is a COOHprotecting group) with a sulfonyl halide compound of the formula: R5-O-R4-SO4-Q (Q is a halogen) and the removing the G1 group of the obtained compound of formula III to obtain the compound of formula IV.

JPH11269094	SUSTAINED RELEASE COMPOSITION, ITS PRODUCTION AND USE
WO/2017/161318	COMPOSITIONS FOR CONTROLLED RELEASE OF CYSTEAMINE AND SYSTEMIC TREATMENT OF CYSTEAMINE SENSITIVE DISORDERS
WO/2000/050454	ANDROGEN-INDUCED SUPPRESSOR OF CELL PROLIFERATION AND USES THEREOF

KIMURA TOMIO
MIYAZAKI SHOJIRO
UEDA KEIJI
TANZAWA KAZUHIKO
USHIYAMA SHIGERU
TAKASAKI WATARU

JP9682799A

November 21, 2000

April 02, 1999

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SANKYO CO

A61K31/00; A61K31/18; A61K31/40; A61K31/401; A61K31/4015; A61K31/403; A61K31/4035; A61K31/415; A61K31/416; A61K31/4166; A61K31/42; A61K31/423; A61K31/425; A61K31/428; A61K31/435; A61K31/4353; A61K31/437; A61K31/44; A61K31/4427; A61K31/4439; A61K31/47; A61K31/472; A61K31/496; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/52; A61K31/522; A61K31/529; A61K31/535; A61K31/536; A61K31/5377; A61K31/54; A61K31/5415; A61P19/00; A61P19/02; A61P29/00; A61P35/00; C07C311/29; C07D207/40; C07D233/74; C07D207/444; C07D209/46; C07D209/48; C07D209/66; C07D217/24; C07D231/56; C07D239/54; C07D239/96; C07D261/20; C07D265/24; C07D275/06; C07D279/08; C07D401/12; C07D417/12; C07D471/04; C07D473/04; C07D473/10; C07D475/02; C07D487/04; C07D495/04; (IPC1-7): C07C311/29; A61P19/02; A61P29/00; A61P35/00; A61K31/18; A61K31/4015; A61K31/4035; A61K31/416; A61K31/42; A61K31/425; A61K31/437; A61K31/4439; A61K31/47; A61K31/506; A61K31/519; A61K31/522; A61K31/536; A61K31/5415; C07D207/40; C07D207/444; C07D209/46; C07D209/48; C07D209/66; C07D217/24; C07D231/56; C07D233/74; C07D239/54; C07D239/96; C07D261/20; C07D265/24; C07D275/06; C07D279/08; C07D401/12; C07D417/12; C07D471/04; C07D473/04; C07D473/10; C07D475/02; C07D487/04; C07D495/04

Akio Ohno (2 outside)

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