Title:
SULFONAMIDE DERIVATIVE
Document Type and Number:
Japanese Patent JP3599287
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new sulfonamide derivative exhibiting strong inhibiting action against cysteine protease such as calpain, cathepsin B, cathepsin H, cathepsin L and papain.
CONSTITUTION: A sulfonamide derivative expressed by the formula I (R is 6-14C aryl or heterocyclic residue which may have one or more substituents) or its salt, e.g. N-phenylsulfonyl-L-leucine-L-valine-methyl ester. The compound of the formula I can be produced e.g. by reacting leucylvaline-methyl ester of the formula II with sulfonyl chloride of the formula III in the presence of a base, reducing the obtained ester compound of the formula IV with a reducing agent to obtain an alcohol of the formula V and oxidizing the alcohol. The compound of the formula I is useful for the treatment of diseases caused by abnormal activation of cysteine protease.
Inventors:
Ryoichi Ando
Toshiro Sakaki
Chisuko Takahashi
Yoshiyuki Fujimura
Toshiro Sakaki
Chisuko Takahashi
Yoshiyuki Fujimura
Application Number:
JP6724294A
Publication Date:
December 08, 2004
Filing Date:
April 05, 1994
Export Citation:
Assignee:
Mitsubishi Chemical Corporation
International Classes:
A61K31/198; A61K31/44; A61K31/4406; A61P3/14; A61P9/00; A61P9/08; A61P9/10; A61P19/10; A61P21/04; A61P25/28; A61P27/02; A61K31/195; A61P27/12; A61P43/00; C07C311/19; C07D209/48; C07D213/71; C07D233/02; C07D233/42; C07D233/84; C07D237/18; C07D237/34; C07D249/12; C07D257/04; C07D309/28; C07D311/58; C07D311/76; C07D333/10; C07D403/12; C07D473/00; C07D475/00; C07K5/06; C12N9/99; (IPC1-7): C07C311/19; A61K31/195; A61K31/44; A61P3/14; A61P9/10; A61P19/10; A61P21/04; A61P25/28; A61P27/12; C07D213/71
Domestic Patent References:
| JP2268145A | ||||
| JP5178758A | ||||
| JP5155764A | ||||
| JP7101924A | ||||
| JP9208545A |
Attorney, Agent or Firm:
Nao Matsuyama
Masao Takayanagi
Hasegawa Soji
Masao Takayanagi
Hasegawa Soji
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