Title:
スルホニルアミノカルボン酸
Document Type and Number:
Japanese Patent JP4177483
Kind Code:
B2
Abstract:
Sulphonamide derivatives of formula (I) and their stereoisomers and salts are new. R1 = Ar or Het; Ar = phenyl (optionally substituted by 1 or 2 alkyl, 3-6C cycloalkyl, OH, alkyl-COO-, alkyl-O-, alkyl-O-(1-4C alkylene)-O-, halo, CF3, CN, NO2, COOH, alkyl-O-CO-, OCH2O, NR4R5CO and NR4R5); Het = pyrrolyl, pyrazolyl, imidazolyl, triazolyl, thienyl, thiazolyl, oxazolyl, isoxazolyl, pyridinyl, pyrimidinyl, indolyl, benzothiophenyl, benzimidazolyl, benzoxazolyl or benzothiazolyl (all optionally substituted as for phenyl in Ar); R2, R4, R5 = H, alkyl, carboxyalkyl, Ar-(CH2)n- (in which Ar is further optionally substituted by 2-4C alkanoylamino) or picolyl; or NR4R5 = 4-7 membered ring (optionally with one C replaced by O, S or NH and optionally having two adjacent C forming part of a benzene residue); n = 0-2; R3 = H, 1-10C alkyl (optionally substituted by OH), 2-10C alkenyl, alkyl substituted by R2O-, R2S(O)m-, R2S(O)n=NH)- or a group of formula (i)); Ar-(CH2)m - (optionally substituted by OH in the (CH2)m chain and in which Ar is further optionally substituted by -O-(CH2)m-Ar and -CO(CH2)mAr); Het-(CH2)m- (optionally substituted by OH in the (CH2)m chain and in which Het is further optionally substituted by CHO, SO2Ar and -O(CH2)m-Ph); -(CH2)m-P(O)(OH)-(1-3C alkyl) or R6CO-alkyl-; or R2+R3 = (CH2)r (in which the obtained ring optionally has one ring C replaced by O, S or NR7 and is optionally substituted by alkyl, Ph, (CH2)mPh and/or OH); W = O, S or N; m = 0-6; r = 1-4; R6 = H, alkyl, Ar, Het or Het-(CH2)m-NH- (both further optionally ring-substituted by carboxy-(1-4C) alkyl), OH, OR2, NR4R5, NHNR4R5 or NHCHR3COOH; R7 = H, alkyl, Ar, CH2Ar or R2N-C(=NH)-; A = bond, O, CH=CH or C IDENTICAL C; B = (CH2)m, O(CH2)p or CH=CH; p = 1-5; X = CH=CH, O or S; and unless specified otherwise alkyl moieties have 1-6C. Also claimed are intermediates of formula (VI) (see "Preparation).
Inventors:
Werner Tallwalt
Will Fleet's Shouvarp
Manfred Shiyudoku
Burghard Hase
Will Fleet's Shouvarp
Manfred Shiyudoku
Burghard Hase
Application Number:
JP16270698A
Publication Date:
November 05, 2008
Filing Date:
May 08, 1998
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07C311/19; A61K31/18; C07D307/54; A61K31/195; A61K31/245; A61K31/275; A61K31/34; A61K31/36; A61K31/38; A61K31/381; A61K31/395; A61K31/396; A61K31/397; A61K31/40; A61K31/403; A61K31/404; A61K31/405; A61K31/41; A61K31/415; A61K31/4184; A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61K31/44; A61K31/4427; A61K31/4433; A61K31/445; A61K31/454; A61K31/63; A61K31/66; A61K31/665; A61K31/67; A61P9/00; A61P9/10; A61P19/00; A61P19/02; A61P19/04; A61P29/00; A61P35/00; A61P35/04; A61P37/00; A61P43/00; C07C311/16; C07C311/29; C07C311/37; C07C311/42; C07C311/44; C07C317/48; C07C323/51; C07C323/58; C07C323/59; C07C381/10; C07D203/06; C07D203/24; C07D205/04; C07D207/12; C07D207/16; C07D207/48; C07D209/08; C07D209/10; C07D209/18; C07D209/20; C07D211/96; C07D213/42; C07D213/55; C07D213/75; C07D233/20; C07D233/54; C07D233/64; C07D235/16; C07D249/06; C07D263/04; C07D277/16; C07D277/20; C07D277/36; C07D295/08; C07D307/58; C07D317/60; C07D333/22; C07D333/24; C07D333/34; C07D333/60; C07D401/12; C07D403/12; C07D409/04; C07D413/04; C07F9/30
Domestic Patent References:
| JP2001521504A | ||||
| JP2001518922A | ||||
| JP2001507342A | ||||
| JP2001526631A | ||||
| JP2000516252A | ||||
| JP2000511175A | ||||
| JP2000502330A | ||||
| JP2000514779A | ||||
| JP6256293A | ||||
| JP9104672A |
Foreign References:
| WO1996000214A1 | ||||
| WO1997027174A1 |
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Kosuke Nishimura