SUPPRESSANT FOR RELAPSE AND KELOPLASTY IN POSTOPERATIVE ANASTOMOSED PART OF INFLAMMATORY BOWEL DISEASE

Japanese Patent JP3919836

B2

PROBLEM TO BE SOLVED: To obtain a suppressant for relapse and keloplasty in a postoperative anastomosed part of inflammatory bowel diseases, comprising a fibrin paste containing a medicine capable of suppressing the production of inflammatory cytokine and leukotriene and capable of manifesting excellent effects on the suppression of relapse and keloplasty in the postoperative anastomosed part of the inflammatory bowel diseases.
SOLUTION: This medicine is capable of suppressing the production of inflammatory cytokine and leukotriene comprises a fibrin paste containing a medicine (preferably ulinastatin, gabexate mesilate, nafamostat mesilate, etc.). The fibrin paste usually comprises a solution containing a fibrinogen dissolved therein such as the fibrinogen or aprotinin or a solution containing thrombin dissolved therein such as thrombin or a calcium liquid. The objective medicine may be prepared by dissolving and blending the fibrinogen or thrombin of the fibrin paste in a solution of the medicine capable of suppressing the production of the cytokine and leukotriene therein. Furthermore, a steroidal agent such as prednisone is preferably additionally blended therewith.

Yagita Asahuni
Fukunaga Nobuto
Seiji Miyamoto

JP21284695A

May 30, 2007

July 28, 1995

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Institute for Chemistry and Serum Therapy
Yagita Asahuni

A61K38/00; A61K31/415; A61K31/435; A61K31/44; A61K31/495; A61K31/56; A61P1/00; A61P41/00; A61P43/00; (IPC1-7): A61K38/00; A61K31/415; A61K31/435; A61K31/44; A61K31/495; A61K31/56

JP63218626A
JP1099565A
JP5000970A
JP2258718A

消化器外科,1993年,Vol.16, No.13,p.1931-1943
日本臨床外科医学会雑誌,1988年,Vol.49, No.4,p.590-596

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