Title:
C型肝炎ウイルスのプロセシングおよび複製の抑制
Document Type and Number:
Japanese Patent JP2004504356
Kind Code:
A
Abstract:
The present invention features methods for inhibiting HCV replication and processing by targeting heat shock protein 90 (HSP90). HSP90 is a cellular chaperone protein that was found to be an essential factor in NS2/3 self-cleavage. HSP90 can be targeted using compounds inhibiting the ability of HSP90 to facilitate NS2/3 cleavage.
Inventors:
Watsuksman, Lloyd H.
Application Number:
JP2002513494A
Publication Date:
February 12, 2004
Filing Date:
July 16, 2001
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
G01N33/50; A61K31/00; A61K31/365; A61K31/395; A61K45/00; A61P31/12; A61P31/14; A61P43/00; C07D225/06; C07D313/00; G01N33/15; G01N33/53; G01N33/566; (IPC1-7): A61K45/00; A61K31/365; A61K31/395; A61P31/14; A61P43/00; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki