Title:
標的検体の検出用のナノ粒子を用いた生体表面弾性波(SAW)共振器増幅
Document Type and Number:
Japanese Patent JP5276655
Kind Code:
B2
Abstract:
The present invention relates generally to a signal amplification method for a SAW resonator microsensor for analyzing test samples, containing target analyte including proteins and nucleic acids. The method comprising the steps: reacting the analyte in a sample with a first molecular recognition component and a second molecular recognition component linked to at least one nanoparticle; and adding an enhancement solution comprising silver ions and/or gold ions, and a reducing agent, whereby the silver ions and/or gold ions are reduced to metallic silver and/or gold which is deposited onto the surface of the at least one nanoparticle; wherein the mass increase of the at least one nanoparticle is detected by a SAW sensor.
Inventors:
Valtu Peter
Application Number:
JP2010509677A
Publication Date:
August 28, 2013
Filing Date:
June 02, 2008
Export Citation:
Assignee:
Atomics Actiesel scab
International Classes:
G01N33/543; G01N29/02
Domestic Patent References:
| JP3503567A | ||||
| JP7260782A | ||||
| JP2006275865A | ||||
| JP2006275864A | ||||
| JP5500715A | ||||
| JP6138125A | ||||
| JP11510247A | ||||
| JP2002202307A | ||||
| JP2005504294A | ||||
| JP2004502950A | ||||
| JP2003287541A |
Foreign References:
| WO2005113817A1 | ||||
| WO2003100386A1 |
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Kobayashi Machiko
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Kobayashi Machiko
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