Title:
徐放性麻酔剤組成物およびその調製方法
Document Type and Number:
Japanese Patent JP7366916
Kind Code:
B2
Abstract:
Provided is an anesthetic composition for locally administering a local anesthetic agent to a subject in need thereof. The anesthetic composition has a lipid based complex prepared by hydrating a lipid cake containing a local anesthetic agent and a lipid mixture with an aqueous buffer solution at a pH higher than 5.5. Also provided is a method to prepare an anesthetic composition using a simpler and more robust for large-scale manufacture and for providing a high molar ratio of local anesthetic agent to phospholipid content as compared to the prior art. This anesthetic composition has a prolonged duration of efficacy adapted to drug delivery.
Inventors:
Hong Keelung
Zen Yun-Ron
Lai Chun-Yen
You One-Knee
Khao Hao-Wen
Lin Yi-You
Zen Yun-Ron
Lai Chun-Yen
You One-Knee
Khao Hao-Wen
Lin Yi-You
Application Number:
JP2020546327A
Publication Date:
October 23, 2023
Filing Date:
March 30, 2019
Export Citation:
Assignee:
TLC By Offer Matthew Ticals, Inc.
Taiwan Liposomes Company Limited
Taiwan Liposomes Company Limited
International Classes:
A61K31/445; A61K9/127; A61K9/19; A61K47/24; A61K47/28; A61P15/06; A61P23/02; A61P25/00; A61P25/04; A61P29/02
Foreign References:
| WO2014046191A1 | ||||
| WO2013146386A1 |
Other References:
Journal of Pharmaceutical Sciences,2004年,Vol.93,pp.1403-1414
Biophysi. J.,1992年,Vol.63,pp.1011-1017
Biophysi. J.,1991年,Vol.59,pp.775-785
Biophysi. J.,1992年,Vol.63,pp.1011-1017
Biophysi. J.,1991年,Vol.59,pp.775-785
Attorney, Agent or Firm:
Kazuhiro Ohta
Kazuko Fujita
Kazuko Fujita
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