Title:
KCNQカリウムチャンネルモジュレーターとしてのシンナミド誘導体
Document Type and Number:
Japanese Patent JP2004535413
Kind Code:
A
Abstract:
There is provided novel cinnamide derivatives of Formula I:wherein R is C1-4 alkyl or trifluoromethyl; R<1 >is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, chromanyl, indanyl, biphenylyl, phenyl and substituted phenyl in which said substituted phenyl is substituted with one or two substituents each independently selected-from the group consisting of halogen, C1-4 alkyl, C1-4 alkoxy, trifluoromethyl, trifluoromethoxy and nitro; R<2 >and R<3 >are each independently selected from the group consisting of hydrogen, C1-4 alkyl, and halogen; R<4 >is selected from the group consisting of di(C1-4 alkyl)amino, trifluoromethoxy and optionally substituted morpholin-4-yl, pyridinyl, pyrimidinyl, piperazinyl, and pyrazinyl with one or two substituents in which said substituent is independently selected from the group consisting of C1-4 alkyl, aminomethyl, hydroxymethyl, chloro or fluoro; R<5 >is hydrogen, chloro or fluoro; or R<4 >and R<5 >taken together are -CH=CH-CH=CH- or -X(CH2)mY- in which X and Y are each independently selected from the group consisting of CH2, (CH2)nN(R<9>)- and O, wherein m is 1 or 2; n is 0 or 1; and R<6>, R<7>, and R<8 >are each independently selected from hydrogen, chloro and fluoro; and R<9 >is selected from the group consisting of hydrogen, C1-4 alkyl, hydroxyethyl, C1-4 alkoxyethyl, cyclopropylmethyl, -CO2(C1-4alkyl), and -CH2CH2NR<10>R<11 >in which R<10 >and R<11 >are each independently hydrogen or C1-4 alkyl, which are openers of the KCNQ potassium channels and are useful in the treatment of disorders which are responsive to the opening of the KCNQ potassium channels.
Inventors:
Young-Jin Woo
Lee Kian Sun
Jae Chen
Juan Hee
Alexander rule
Pierre Dextras
Jean-Paul Dali
Gene Gee Kinney
Stephen I Dowletsky
Pyasena Hewawasam
Lee Kian Sun
Jae Chen
Juan Hee
Alexander rule
Pierre Dextras
Jean-Paul Dali
Gene Gee Kinney
Stephen I Dowletsky
Pyasena Hewawasam
Application Number:
JP2003500038A
Publication Date:
November 25, 2004
Filing Date:
May 31, 2002
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/165; A61K31/343; A61K31/353; A61K31/357; A61K31/36; A61K31/381; A61K31/404; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/47; A61K31/472; A61K31/495; A61K31/4965; A61K31/505; A61K31/537; A61K31/5375; A61K31/538; A61P1/00; A61P9/10; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07C233/11; C07C235/34; C07D209/08; C07D213/40; C07D213/56; C07D213/61; C07D215/04; C07D215/12; C07D217/06; C07D239/26; C07D241/12; C07D265/30; C07D265/36; C07D295/135; C07D307/78; C07D307/79; C07D311/04; C07D311/58; C07D317/58; C07D295/12; C07D317/60; C07D319/18; C07D333/24; C07D407/12; C07D491/08; (IPC1-7): C07C233/11; A61K31/165; A61K31/343; A61K31/353; A61K31/357; A61K31/36; A61K31/381; A61K31/404; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/47; A61K31/472; A61K31/495; A61K31/4965; A61K31/505; A61K31/537; A61K31/5375; A61K31/538; A61P1/00; A61P9/10; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07D209/08; C07D213/40; C07D213/56; C07D213/61; C07D215/12; C07D217/06; C07D239/26; C07D241/12; C07D265/30; C07D265/36; C07D295/12; C07D307/78; C07D311/04; C07D317/58; C07D319/18; C07D333/24; C07D407/12; C07D491/08
Attorney, Agent or Firm:
Kyousei Tamura
Toshio Ueda
Nagatoshi Shinagawa
Toshio Ueda
Nagatoshi Shinagawa