Title:
磁気粒子イメージング(MPI)のための高性能鉄酸化物粒子トレーサーの合成
Document Type and Number:
Japanese Patent JP2013529677
Kind Code:
A
Abstract:
The present invention relates to a method of forming iron oxide nanoparticles comprising the steps of (a) suspending iron oxide/hydroxide and oleic acid or a derivative thereof in a primary organic solvent; (b) increasing the temperature of the suspension by a defined rate up to a maximum of 340° C. to 500° C.; (c) aging the suspension at the maximum temperature of step (b) for about 0.5 to 6 h; (d) cooling the suspension; (e) adding a secondary organic solvent; (f) precipitating nanoparticles by adding a non-solvent and removing excess solvent; (g) dispersing said nanoparticles in said secondary organic solvent; (h) mixing the dispersion of step (g) with a solution of a polymer; and (i) optionally removing said secondary organic solvent. The present invention further relates to an iron oxide nanoparticle obtainable by the method, the additional modification, encapsulation and decoration of such nanoparticles, as well as the use of the nanoparticles as tracers for Magnetic Particle Imaging (MPI), Magnetic Particle Spectroscopy (MPS).
Inventors:
Burdinsky, Dirk
Bollender, Carmen
Harks, Nicolet Petronella Martin
Bollender, Carmen
Harks, Nicolet Petronella Martin
Application Number:
JP2013517614A
Publication Date:
July 22, 2013
Filing Date:
June 21, 2011
Export Citation:
Assignee:
Koninklijke Philips Electronics N.V.
International Classes:
A61K49/00; A61K9/00; A61K9/06; A61K9/127; A61K9/48; A61K41/00; A61P5/00; A61P5/14; A61P7/02; A61P7/06; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/08
Domestic Patent References:
| JP2005286306A | 2005-10-13 |
Foreign References:
| CN101538068A | 2009-09-23 |
Other References:
JPN5013008052; ＧＵＰＴＡ Ａ． Ｋ．: 'ＳＹＮＴＨＥＳＩＳ ＡＮＤ ＳＵＲＦＡＣＥ ＥＮＧＩＮＥＥＲＩＮＧ ＯＦ ＩＲＯＮ ＯＸＩＤＥ ＮＡＮＯＰＡＲＴＩＣＬＥＳ ＦＯＲ ＢＩＯＭＥＤＩＣＡＬ ＡＰＰＬＩＣＡＴＩＯＮＳ' ＢＩＯＭＡＴＥＲＩＡＬＳ Ｖ２６ Ｎ１８, 20050601, Ｐ３９９５，４０００-４００４，４０１２-４０１３, ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ ＰＵＢＬＩＳＨＥＲＳ Ｂ．Ｖ．
JPN5013008053; Ｍ． Ａ． ＭＯＲＡＬＥＳ: 'ＭＡＧＮＥＴＩＣ ＳＴＵＤＩＥＳ ＯＦ ＩＲＯＮ ＯＸＩＤＥ ＮＡＮＯＰＡＲＴＩＣＬＥＳ ＣＯＡＴＥＤ ＷＩＴＨ ＯＬＥＩＣ ＡＣＩＤ ＡＮＤ ＰＬＵＲＯＮＩＣ ＢＬＯＣＫ ＣＯＰＯＬＹＭＥＲ' ＪＯＵＲＮＡＬ ＯＦ ＡＰＰＬＩＥＤ ＰＨＹＳＩＣＳ Ｖ９７ Ｎ１０, 20050101, Ｐ１０Ｑ９０５
JPN5013008054; ＧＯＮＺＡＬＥＳ: 'ＰＨＡＳＥ ＴＲＡＮＳＦＥＲ ＯＦ ＨＩＧＨＬＹ ＭＯＮＯＤＩＳＰＥＲＳＥ ＩＲＯＮ ＯＸＩＤＥ ＮＡＮＯＣＲＹＳＴＡＬＳ ＷＩＴＨ ＰＬＵＲＯＮＩＣ Ｆ１２７ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＭＡＧＮＥＴＩＳＭ ＡＮＤ ＭＡＧＮＥＴＩＣ ＭＡＴＥＲＩＡＬＳ Ｖ３１１ Ｎ１, 20070315, Ｐ５９-６２, ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ ＰＵＢＬＩＳＨＥＲＳ
JPN5013008051; ＹＵ ＷＩＬＬＩＡＭ Ｗ．: 'ＳＹＮＴＨＥＳＩＳ ＯＦ ＭＯＮＯＤＩＳＰＥＲＳＥ ＩＲＯＮ ＯＸＩＤＥ ＮＡＮＯＣＲＹＳＴＡＬＳ ＢＹ ＴＨＥＲＭＡＬ ＤＥＣＯＭＰＯＳＩＴＩＯＮ ＯＦ ＩＲＯＮ ＣＡＲＢＯＸＹＬＡＴＥ ＳＡＬＴＳ' ＣＨＥＭＩＣＡＬ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ - ＣＨＥＭＣＯＭ； ［６０１５Ｄ］ , 20040902, Ｐ２３０６-２３０７, ＲＯＹＡＬ ＳＯＣＩＥＴＹ ＯＦ ＣＨＥＭＩＳＴＲＹ
JPN5013008050; ＪＡＮＡ ＮＩＫＨＩＬ Ｒ．: 'ＳＩＺＥ- ＡＮＤ ＳＨＡＰＥ-ＣＯＮＴＲＯＬＬＥＤ ＭＡＧＮＥＴＩＣ （ＣＲ， ＭＮ， ＦＥ， ＣＯ， ＮＩ） ＯＸＩＤＥ ＮＡＮＯＣＲＹＳＴＡＬＳ ＶＩＡ Ａ ＳＩＭＰＬＥ 以下備考' ＣＨＥＭＩＳＴＲＹ ＯＦ ＭＡＴＥＲＩＡＬＳ Ｖ１６ Ｎ２０, 20041005, Ｐ３９３１-３９３５, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN6015020882; ＡＤＶＡＮＣＥＤ ＦＵＮＣＴＩＯＮＡＬ ＭＡＴＥＲＩＡＬＳ Ｖｏｌ．１９， Ｉｓｓｕｅ ８, 2009, ｐ．１１５８-６６
JPN5013008053; Ｍ． Ａ． ＭＯＲＡＬＥＳ: 'ＭＡＧＮＥＴＩＣ ＳＴＵＤＩＥＳ ＯＦ ＩＲＯＮ ＯＸＩＤＥ ＮＡＮＯＰＡＲＴＩＣＬＥＳ ＣＯＡＴＥＤ ＷＩＴＨ ＯＬＥＩＣ ＡＣＩＤ ＡＮＤ ＰＬＵＲＯＮＩＣ ＢＬＯＣＫ ＣＯＰＯＬＹＭＥＲ' ＪＯＵＲＮＡＬ ＯＦ ＡＰＰＬＩＥＤ ＰＨＹＳＩＣＳ Ｖ９７ Ｎ１０, 20050101, Ｐ１０Ｑ９０５
JPN5013008054; ＧＯＮＺＡＬＥＳ: 'ＰＨＡＳＥ ＴＲＡＮＳＦＥＲ ＯＦ ＨＩＧＨＬＹ ＭＯＮＯＤＩＳＰＥＲＳＥ ＩＲＯＮ ＯＸＩＤＥ ＮＡＮＯＣＲＹＳＴＡＬＳ ＷＩＴＨ ＰＬＵＲＯＮＩＣ Ｆ１２７ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＭＡＧＮＥＴＩＳＭ ＡＮＤ ＭＡＧＮＥＴＩＣ ＭＡＴＥＲＩＡＬＳ Ｖ３１１ Ｎ１, 20070315, Ｐ５９-６２, ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ ＰＵＢＬＩＳＨＥＲＳ
JPN5013008051; ＹＵ ＷＩＬＬＩＡＭ Ｗ．: 'ＳＹＮＴＨＥＳＩＳ ＯＦ ＭＯＮＯＤＩＳＰＥＲＳＥ ＩＲＯＮ ＯＸＩＤＥ ＮＡＮＯＣＲＹＳＴＡＬＳ ＢＹ ＴＨＥＲＭＡＬ ＤＥＣＯＭＰＯＳＩＴＩＯＮ ＯＦ ＩＲＯＮ ＣＡＲＢＯＸＹＬＡＴＥ ＳＡＬＴＳ' ＣＨＥＭＩＣＡＬ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ - ＣＨＥＭＣＯＭ； ［６０１５Ｄ］ , 20040902, Ｐ２３０６-２３０７, ＲＯＹＡＬ ＳＯＣＩＥＴＹ ＯＦ ＣＨＥＭＩＳＴＲＹ
JPN5013008050; ＪＡＮＡ ＮＩＫＨＩＬ Ｒ．: 'ＳＩＺＥ- ＡＮＤ ＳＨＡＰＥ-ＣＯＮＴＲＯＬＬＥＤ ＭＡＧＮＥＴＩＣ （ＣＲ， ＭＮ， ＦＥ， ＣＯ， ＮＩ） ＯＸＩＤＥ ＮＡＮＯＣＲＹＳＴＡＬＳ ＶＩＡ Ａ ＳＩＭＰＬＥ 以下備考' ＣＨＥＭＩＳＴＲＹ ＯＦ ＭＡＴＥＲＩＡＬＳ Ｖ１６ Ｎ２０, 20041005, Ｐ３９３１-３９３５, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN6015020882; ＡＤＶＡＮＣＥＤ ＦＵＮＣＴＩＯＮＡＬ ＭＡＴＥＲＩＡＬＳ Ｖｏｌ．１９， Ｉｓｓｕｅ ８, 2009, ｐ．１１５８-６６
Attorney, Agent or Firm:
Tadashige Ito
Tadahiko Ito
Shinsuke Onuki
Tadahiko Ito
Shinsuke Onuki