Title:
不均一系金属触媒反応によるアルデヒドまたはケトンからのアミドおよびアミンの合成
Document Type and Number:
Japanese Patent JP6440132
Kind Code:
B2
Abstract:
A mild and efficient synthesis of primary amines and amides from aldehydes or ketones using a heterogeneous metal catalyst and amine donor is disclosed. The initial heterogeneous metal-catalyzed reaction between the carbonyl and the amine donor components is followed by the addition of a suitable acylating agent component in one-pot, thus providing a catalytic one-pot three-component synthesis of amides. Integration of enzyme catalysis allows for eco-friendly one-pot co-catalytic synthesis of amides from aldehyde and ketone substrates, respectively. The process can be applied to asymmetric synthesis or to the co-catalytic one-pot three-component synthesis of capsaicin and its analogues from vanillin or vanillyl alcohol. A co-catalytic reductive amination/dynamic kinetic resolution (dkr) relay sequence for the asymmetric synthesis of optically active amides from ketones is disclosed. Implementation of a catalytic reductive amination/kinetic resolution (kr) relay sequence produces the corresponding optically active amide product and optical active primary amine product with the opposite stereochemistry from the starting ketones.
Inventors:
Cordoba, Armando
Paro-Nieto, Carlos
Afewerki, Samsung
Paro-Nieto, Carlos
Afewerki, Samsung
Application Number:
JP2017530139A
Publication Date:
December 19, 2018
Filing Date:
December 15, 2015
Export Citation:
Assignee:
Organo Fool Sweden Ab
International Classes:
C07C209/24; A61K31/165; A61P43/00; C07C211/06; C07C211/07; C07C211/17; C07C211/27; C07C211/29; C07C213/02; C07C217/58; C07C227/08; C07C229/08; C07C231/02; C07C233/05; C07C233/06; C07C233/18; C07C233/20; C07C233/22; C07D307/52; C07D317/50; C12N9/10; C12N9/20; C12N11/08; C12P13/02
Domestic Patent References:
| JP5310653A | ||||
| JP2004537588A | ||||
| JP11206396A |
Other References:
Mattias Anderson et al.,Adv. Synth. Catal.,2014年 4月15日,356,pp.2113-2118
Attorney, Agent or Firm:
Longhua International Patent Service Corporation
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