Title:
エポシロン類及び関連類似体の合成
Document Type and Number:
Japanese Patent JP2005500974
Kind Code:
A
Abstract:
The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: and stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.
More Like This:
Inventors:
Avery, Mitchell, A
Application Number:
JP2002533803A
Publication Date:
January 13, 2005
Filing Date:
October 15, 2001
Export Citation:
Assignee:
The University of Mississippi
International Classes:
A61K31/335; A61K31/427; A61P35/00; C07B51/00; C07B53/00; C07C17/093; C07C17/16; C07C45/29; C07C45/30; C07C45/41; C07C47/263; C07C47/277; C07C51/06; C07C51/353; C07C59/215; C07C59/76; C07D275/06; C07D277/24; C07D277/30; C07D313/00; C07D417/06; C07D493/04; C07F7/18; (IPC1-7): C07D313/00; A61K31/335; A61K31/427; A61P35/00; C07C45/30; C07C45/41; C07C47/263; C07C51/06; C07C51/353; C07C59/215; C07C59/76; C07D277/24; C07D417/06; C07D493/04; C07F7/18
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda