Title:
三酸化硫黄複合体を用いる、硫酸化エストロゲンの混合物の合成
Document Type and Number:
Japanese Patent JP2005515222
Kind Code:
A
Abstract:
A process of producing a stable composition comprising a mixture of sulfated estrogens. The mixture of sulfated estrogens may comprise sulfated alkali metal salts of Delta8,9-dehydroestrone, estrone, and derivatives thereof or other estrogens. The process comprises the steps of sulfating such mixture of alkali metal salts of Delta8,9-dehydroestrone, estrone, and derivatives thereof with a sulfur trioxide complex and adding tris(hydroxymethyl)aminomethane.
Inventors:
Leonard, Thomas W
Application Number:
JP2003558157A
Publication Date:
May 26, 2005
Filing Date:
January 07, 2003
Export Citation:
Assignee:
Bar Laboratories, Inc.
International Classes:
C07J31/00; (IPC1-7): C07J31/00
Domestic Patent References:
| JPH1149795A | 1999-02-23 | |||
| JPH07504197A | 1995-05-11 |
Foreign References:
| US4154820A | 1979-05-15 | |||
| US6458778B1 | 2002-10-01 | |||
| US5998638A | 1999-12-07 | |||
| US6525039B1 | 2003-02-25 | |||
| GB1262971A | 1972-02-09 | |||
| EP0380021A2 | 1990-08-01 |
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo