Title:
SYNTHESIS OF PHARMACOLOGICALLY ACTIVE COMPOUND AND INTERMEDIATE THEREFOR
Document Type and Number:
Japanese Patent JPS6147447
Kind Code:
A
Abstract:
(57) A process for the preparation of an aryloxypropanolamine of the formulawherein Ar is a carbocyclic or heterocyclic aromatic group and R is an alkyl or substituted alkyl group having 1 to 6 carbon atoms, characterized in subjecting a compound of the formulato oxidative deavage to a dialdehyde of the formulawhich is then made subject to reduction, amination, acetal hydrolysis, and, where required, removal of a nitrogen protective group, to the formation of a compound of formula I, or an acid accition salt thereof, a compound of formula II and the preparation thereof from mannitol.
Inventors:
BUU ROBERUTO RAMU
Application Number:
JP17598385A
Publication Date:
March 07, 1986
Filing Date:
August 12, 1985
Export Citation:
Assignee:
HAESSLE AB
International Classes:
C07C67/00; C07C213/00; C07C217/32; C07D295/16; C07D521/00; C07D295/18; C07D295/182; C07D321/06; C07D405/12; C07D417/14; (IPC1-7): C07C89/00; C07C93/06; C07D321/06; C07D521/00
Attorney, Agent or Firm:
Chika Takagi